Department of Surgery, College of Medicine, Imam Abdulrahman Bin Faisal University, Al Khobar, Saudi Arabia.
J Med Case Rep. 2023 Jun 30;17(1):296. doi: 10.1186/s13256-023-03993-z.
Primary hepatic neuroendocrine tumours (PHNETs) are a rare form of hepatic neoplasms, and it is difficult to differentiate them from common hepatic malignancies in routine imaging studies.
We describe the case of a 60-year-old Indian male patient with a tentative preoperative diagnosis of hepatocellular carcinoma (HCC). Nevertheless, the definitive post-operative diagnosis was made by Histopathological and immunohistochemical assessment, which revealed a grade II neuroendocrine tumour (NET) of moderate differentiation. Surgical resection was performed through a minimally invasive approach with a favourable postoperative course and a short hospital stay. One-month Post-operative Octreotide scan showed no extrahepatic primary origin of the tumour.
PHNET is a rare entity, and multi modalities investigations, including imaging, serology, endoscopy series, and histopathology findings, aside from long-term follow-up to rule out another primary origin, are essential for the final diagnosis of PHNET. Surgical resection stands as the mainstay of treatment of PHNETs.
The absence of primary liver diseases should expand our possible differential diagnosis. Laparoscopic surgical resection of PHNETs carries a favourable outcome.
原发性肝神经内分泌肿瘤（PHNET）是一种罕见的肝肿瘤，在常规影像学研究中很难将其与常见的肝恶性肿瘤区分开来。
我们描述了一位 60 岁的印度男性患者的病例，术前诊断为肝细胞癌（HCC）。然而，通过组织病理学和免疫组织化学评估，明确诊断为 II 级中度分化神经内分泌肿瘤（NET）。手术通过微创方式进行，术后恢复良好，住院时间短。术后 1 个月奥曲肽扫描未见肿瘤的肝外原发灶。
PHNET 较为罕见，需要多种方法的检查，包括影像学、血清学、内镜系列和组织病理学检查，以及长期随访以排除另一个原发灶，这对于 PHNET 的最终诊断至关重要。手术切除是治疗 PHNET 的主要方法。
没有原发性肝病时，应扩大我们的鉴别诊断范围。腹腔镜手术切除 PHNET 具有良好的预后。
