Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cell. 2020 Jun 25;181(7):1464-1474. doi: 10.1016/j.cell.2020.06.004.
Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. However, a gap remains in identifying the detailed molecular signals induced by exercise that benefits health and prevents disease. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this gap and generate a molecular map of exercise. Preclinical and clinical studies will examine the systemic effects of endurance and resistance exercise across a range of ages and fitness levels by molecular probing of multiple tissues before and after acute and chronic exercise. From this multi-omic and bioinformatic analysis, a molecular map of exercise will be established. Altogether, MoTrPAC will provide a public database that is expected to enhance our understanding of the health benefits of exercise and to provide insight into how physical activity mitigates disease.
运动提供了强大的生理刺激，引发了多种组织之间的交流，当这种刺激被定期重复（即训练）时，它可以提高生理能力，有益于众多器官系统，并降低过早死亡的风险。然而，在确定运动所诱导的有益于健康和预防疾病的详细分子信号方面仍然存在差距。物理活动的分子转导者联盟（MoTrPAC）的成立就是为了填补这一空白，并生成运动的分子图谱。通过对急性和慢性运动前后的多种组织进行分子探测，临床前和临床研究将检查耐力和抗阻运动在不同年龄和健康水平下的系统效应。通过这种多组学和生物信息学分析，将建立运动的分子图谱。总的来说，MoTrPAC 将提供一个公共数据库，有望增强我们对运动健康益处的理解，并深入了解体育活动如何减轻疾病。
