A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models.
作者信息
Loontiens Siebe, Vanhauwaert Suzanne, Depestel Lisa, Dewyn Givani, Van Loocke Wouter, Moore Finola E, Garcia Elaine G, Batchelor Lance, Borga Chiara, Squiban Barbara, Malone-Perez Megan, Volders Pieter-Jan, Olexiouk Volodimir, Van Vlierberghe Pieter, Langenau David M, Frazer J Kimble, Durinck Kaat, Speleman Frank
机构信息
Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
出版信息
Leukemia. 2020 Dec;34(12):3398-3403. doi: 10.1038/s41375-020-0938-2. Epub 2020 Jun 26.
Abstract
摘要
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Front Oncol. 2019 Sep 13;9:871. doi: 10.3389/fonc.2019.00871. eCollection 2019.
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Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL.缺失增强了 HSC 的自我更新，从而驱动 T-ALL 中的肿瘤起始和白血病干细胞活性。
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