Bertini R, Bianchi M, Ghezzi P
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
J Exp Med. 1988 May 1;167(5):1708-12. doi: 10.1084/jem.167.5.1708.
To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally prevented by pretreatment with dexamethasone (minimal effective dose, 0.3 mg/Kg) but not by ibuprofen (10 mg/Kg).
为阐明肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）在内毒素休克中可能发挥的作用，研究了重组TNF（人源和鼠源）及IL-1对肾上腺切除小鼠的致死性。肾上腺切除术长期以来被认为会增加对内毒素的易感性，就死亡率而言，使小鼠对TNF和IL-1易感。地塞米松（最小有效剂量，0.3毫克/千克）预处理可完全预防内毒素、TNF或IL-1的致死性，但布洛芬（10毫克/千克）预处理则不能。
