通过体内抗L3T4治疗预防II型胶原诱导的关节炎。
Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.
作者信息
Ranges G E, Sriram S, Cooper S M
出版信息
J Exp Med. 1985 Sep 1;162(3):1105-10. doi: 10.1084/jem.162.3.1105.
Abstract
The effect of in vivo administration of monoclonal anti-L3T4 antibody on the development of murine collagen-induced arthritis (CIA) was assessed. Treatment with anti-L3T4 resulted in a greater than 90% depletion of L3T4+ T cells in lymph nodes and spleen, an effect that appears entirely reversed 30 d after treatment. Administration of anti-L3T4 before immunization with type II collagen resulted in a significant decrease in arthritis incidence and delayed onset of the disease while treatment begun after a strong anticollagen IgG humoral response was underway was not effective in altering disease expression. These results suggest a prominent role for L3T4+ T cells in the pathogenesis of CIA.
摘要
评估了体内给予单克隆抗L3T4抗体对小鼠胶原诱导性关节炎（CIA）发展的影响。用抗L3T4治疗导致淋巴结和脾脏中L3T4 + T细胞减少超过90%，这种效应在治疗后30天似乎完全逆转。在用II型胶原免疫前给予抗L3T4导致关节炎发病率显著降低且疾病发作延迟，而在强烈的抗胶原IgG体液反应开始后开始治疗对改变疾病表现无效。这些结果表明L3T4 + T细胞在CIA发病机制中起重要作用。
相似文献
1
Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.通过体内抗L3T4治疗预防II型胶原诱导的关节炎。
J Exp Med. 1985 Sep 1;162(3):1105-10. doi: 10.1084/jem.162.3.1105.
2
3
Interleukin-1 enhances the development of type II collagen-induced arthritis only in susceptible and not in resistant mice.白细胞介素-1仅在易患性小鼠而非抗性小鼠中增强II型胶原诱导的关节炎的发展。
Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 1):56-65. doi: 10.1016/0090-1229(92)90022-g.
4
The progression of the inflammation in established collagen-induced arthritis can be altered by treatments with immunological or pharmacological agents which inhibit T cell activities.在已建立的胶原诱导性关节炎中，炎症的进展可通过使用抑制T细胞活性的免疫或药理制剂进行治疗而改变。
Eur J Immunol. 1988 Jun;18(6):881-8. doi: 10.1002/eji.1830180608.
5
Effects of various anti-T cell receptor antibodies on the development of type II collagen-induced arthritis in mice.各种抗T细胞受体抗体对小鼠II型胶原诱导性关节炎发展的影响。
Immunol Invest. 1993 Jun;22(4):257-65. doi: 10.3109/08820139309063407.
6
7
8
Type II collagen-induced murine arthritis. II. Genetic control of arthritis induction is expressed on L3T4+ T cells required for humoral as well as cell-mediated immune responses to type II collagen.II型胶原诱导的小鼠关节炎。II. 关节炎诱导的遗传控制在对II型胶原的体液免疫和细胞介导免疫反应所需的L3T4 + T细胞上表达。
Reg Immunol. 1989 Jul-Aug;2(4):203-12.
9
Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4.体内长期体液无反应性，由抗L3T4单克隆抗体治疗诱导产生。
J Exp Med. 1986 Sep 1;164(3):911-25. doi: 10.1084/jem.164.3.911.
10
Analysis of the function of L3T4+ T cells by in vivo treatment with monoclonal antibody to L3T4.通过用抗L3T4单克隆抗体进行体内治疗来分析L3T4 + T细胞的功能。
Immunol Res. 1986;5(2):97-105. doi: 10.1007/BF02917584.
引用本文的文献
1
Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment.胶原蛋白在类风湿性关节炎中的矛盾双重作用：炎症原因与治疗方法
Bioengineering (Basel). 2022 Jul 15;9(7):321. doi: 10.3390/bioengineering9070321.
2
Inflammation and Bone Metabolism in Rheumatoid Arthritis: Molecular Mechanisms of Joint Destruction and Pharmacological Treatments.类风湿关节炎中的炎症和骨代谢：关节破坏的分子机制和药物治疗。
Int J Mol Sci. 2022 Mar 6;23(5):2871. doi: 10.3390/ijms23052871.
3
Schistosome infection promotes osteoclast-mediated bone loss.血吸虫感染促进破骨细胞介导的骨质流失。
PLoS Pathog. 2021 Mar 18;17(3):e1009462. doi: 10.1371/journal.ppat.1009462. eCollection 2021 Mar.
4
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.内收蛋白 A2 缺乏通过调节 T 细胞活化来保护啮齿动物免受自身免疫性关节炎的侵害。
Nat Commun. 2021 Jan 27;12(1):610. doi: 10.1038/s41467-020-20586-2.
5
TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model.TRI 微球可预防胶原诱导性关节炎模型中的炎症性关节炎。
PLoS One. 2020 Sep 23;15(9):e0239396. doi: 10.1371/journal.pone.0239396. eCollection 2020.
6
Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies.类风湿关节炎的人源化小鼠模型用于免疫发病机制研究和基于细胞的疗法的临床前测试。
Front Immunol. 2019 Feb 19;10:203. doi: 10.3389/fimmu.2019.00203. eCollection 2019.
7
Immune-bone interplay in the structural damage in rheumatoid arthritis.类风湿关节炎结构损伤中的免疫-骨骼相互作用。
Clin Exp Immunol. 2018 Oct;194(1):1-8. doi: 10.1111/cei.13188. Epub 2018 Sep 4.
8
Osteoimmunology.骨免疫学。
Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):a031245. doi: 10.1101/cshperspect.a031245.
9
Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity.更新骨免疫学：固有免疫和适应性免疫对骨细胞的调节。
Nat Rev Rheumatol. 2018 Mar;14(3):146-156. doi: 10.1038/nrrheum.2017.213. Epub 2018 Jan 11.
10
Effects of VLA-1 Blockade on Experimental Inflammation in Mice.VLA-1阻断对小鼠实验性炎症的影响。
Kobe J Med Sci. 2016 Jul 5;62(2):E27-37.
本文引用的文献
1
Serum transfer of collagen-induced arthritis in mice.小鼠胶原诱导性关节炎的血清转移
J Exp Med. 1983 Aug 1;158(2):378-92. doi: 10.1084/jem.158.2.378.
2
Passive transfer of arthritis to mice by injection of human anti-type II collagen antibody.通过注射人抗II型胶原抗体将关节炎被动转移至小鼠。
Mayo Clin Proc. 1984 Nov;59(11):737-43. doi: 10.1016/s0025-6196(12)65583-9.
3
4
Collagen autoimmune arthritis.胶原性自身免疫性关节炎
Annu Rev Immunol. 1984;2:199-218. doi: 10.1146/annurev.iy.02.040184.001215.
5
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.被单克隆抗体GK1.5识别的、命名为L3T4a的鼠类抗原决定簇的特性：功能性T细胞克隆对L3T4a的表达似乎主要与II类主要组织相容性复合体（MHC）抗原反应性相关。
Immunol Rev. 1983;74:29-56. doi: 10.1111/j.1600-065x.1983.tb01083.x.
6
7
Immunisation against heterologous type II collagen induces arthritis in mice.针对异源II型胶原蛋白进行免疫接种会在小鼠中诱发关节炎。
Nature. 1980 Feb 14;283(5748):666-8. doi: 10.1038/283666a0.
8
Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.用抗L3T4单克隆抗体成功治疗NZB/NZW F1小鼠的自身免疫病。
J Exp Med. 1985 Feb 1;161(2):378-91. doi: 10.1084/jem.161.2.378.
9
Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker.用针对T细胞亚群标志物的单克隆抗体逆转实验性变应性脑脊髓炎
Science. 1985 Jan 25;227(4685):415-7. doi: 10.1126/science.3155574.
10
Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats.大鼠II型胶原诱导性关节炎中对胶原的体液和细胞敏感性
J Clin Invest. 1978 Jan;61(1):89-96. doi: 10.1172/JCI108929.
Zotero 插件