The Department of Radiology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; The Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
China Academy of Information and Communications Technology, Beijing, China; Ping An Technology (Shenzhen) Company Limited, Shenzhen, China.
Eur J Radiol. 2020 Aug;129:109119. doi: 10.1016/j.ejrad.2020.109119. Epub 2020 Jun 6.
In this study, we used magnetic resonance imaging (MRI) to investigate the anatomical alterations of cerebral cortex in children with Tourette syndrome (TS) and explore whether such deficits were related with their clinical symptoms.
All subjects were scanned in a 3.0T MRI scanner with three-dimensional T1-weighted images (3DT1WI). Then, some surface-based features were extracted by using the FreeSurfer software. After that, the between-group differences of those features were assessed.
Sixty TS patients and 52 age- and gender-matched healthy control were included in this study. Surface-based analyses revealed altered cortical thickness, cortical sulcus, cortical curvature and local gyrification index (LGI) in TS group compared with healthy controls. The brain regions with significant-group differences in cortical thickness included postcentral gyrus, superiorparietal gyrus, rostral anterior cingulate cortex in the left hemisphere and frontal pole, lateral occipital gyrus, inferior temporal gyrus in the right hemisphere. In addition, the superior temporal gyrus, medial orbitofrontal gyrus, supramarginal gyrus, medial orbitofrontal gyrus, superiorparietal gyrus and lateral occipital gyrus showed significant between-group differences for cortical sulcus. Moreover, the brain regions with significant between-group differences in cortical curvature were located in caudal anterior cingulate cortex, supramarginal gyrus, inferior parietal gyrus and lateral occipital gyrus. The alteration of LGI were most prominent in the inferior temporal gyrus and insula. Additionally, there was no statistical difference in brain surface area for TS children compared with controls.
The results of this study revealed that cortical thickness, sulcus, cortical curvature and LGI were changed in multiple brain regions for children with TS.
本研究采用磁共振成像（MRI）技术探讨抽动障碍（TS）患儿大脑皮层的解剖结构改变，并探讨这些缺陷是否与临床症状相关。
所有受试者均在 3.0T MRI 扫描仪上进行三维 T1 加权成像（3DT1WI）扫描。然后，使用 FreeSurfer 软件提取基于表面的特征。之后，评估这些特征的组间差异。
本研究纳入了 60 例 TS 患儿和 52 名年龄和性别匹配的健康对照。基于表面的分析显示，与健康对照组相比，TS 组的皮质厚度、皮质沟回、皮质曲率和局部脑回指数（LGI）存在差异。皮质厚度存在显著组间差异的脑区包括左侧后中央回、上顶叶、额前扣带回皮质，以及右侧额极、外侧枕叶、颞下回。此外，在颞上回、眶额内侧回、缘上回、眶额内侧回、顶叶上回和外侧枕叶也观察到皮质沟回存在显著的组间差异。另外，在扣带回皮质后段、缘上回、顶下小叶和外侧枕叶也观察到皮质曲率存在显著的组间差异。LGI 的改变在颞下回和岛叶最为明显。此外，与对照组相比，TS 患儿的脑表面积无统计学差异。
本研究结果表明，TS 患儿的多个脑区存在皮质厚度、沟回、皮质曲率和 LGI 的改变。
