Moreau Isabel, Hébert Marc, Maziade Michel, Painchaud Alexandra, Mérette Chantal
Centre de recherche CERVO, Centre intégré de santé et de services sociaux de la Capitale-Nationale, Québec, QC, Canada.
Département d'informatique et de génie logiciel, Université Laval, Québec, QC, Canada.
Schizophr Bull Open. 2022 Feb 5;3(1):sgac016. doi: 10.1093/schizbullopen/sgac016. eCollection 2022 Jan.
We previously proposed the electroretinogram (ERG) as a promising biomarker of major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP), given that we found anomalies in the ERG parameters of patients with these diagnoses as well as in their children who are at high risk (HR) of developing such disorders. The aim of the present study is to investigate the usefulness of the ERG for individual detection, among HR children, of an ERG profile resembling that of a SZ patient, as this may indicate a stronger likelihood of transition to psychosis. Using a logistic regression model previously derived from the ERG assessments of SZ patients and control (CT) subjects, individual risk scores were obtained for 61 HR and 80 CT youth. Those with a very high individual risk score were classified as "schizophrenia-like" (). We found that the HR subjects were 3.5 times more likely to be classified as than the CT subjects (95% CI [1.1-11.8]). Furthermore, among the HR subjects, we studied the relationship between the classification and psychotic-like experiences and found that HR subjects classified as were 2.7 times more likely than all remaining HR subjects to have experienced psychotic-like symptoms (95% CI [1.3-4.6]), and 6.8 times more likely than those with a very low individual risk score (95% CI [1.4-40.4]). Our results suggest that a model previously derived from ERG data on SZ patients could be a potential tool for early detection of the susceptibility to a psychotic-like disorder among familial HR children.
鉴于我们发现患有精神分裂症（SZ）和双相情感障碍（BP）等主要精神疾病的患者及其有患此类疾病高风险（HR）的子女的视网膜电图（ERG）参数存在异常，我们之前提出ERG有望成为这些主要精神疾病的生物标志物。本研究的目的是调查ERG在HR儿童中用于个体检测类似于SZ患者ERG特征的效用，因为这可能表明向精神病转变的可能性更大。使用先前从SZ患者和对照（CT）受试者的ERG评估得出的逻辑回归模型，为61名HR和80名CT青少年获得了个体风险评分。个体风险评分非常高的那些人被归类为“精神分裂症样”（）。我们发现，HR受试者被归类为的可能性是CT受试者的3.5倍（95%置信区间[1.1 - 11.8]）。此外，在HR受试者中，我们研究了分类与类精神病体验之间的关系，发现被归类为的HR受试者出现类精神病症状的可能性是所有其余HR受试者的2.7倍（95%置信区间[1.3 - 4.6]），是个体风险评分非常低的那些人的6.8倍（95%置信区间[1.4 - 40.4]）。我们的结果表明，先前从SZ患者的ERG数据得出的模型可能是一种早期检测家族性HR儿童患类精神病性障碍易感性的潜在工具。
