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Neurotrophin-3-mediated locomotor recovery: a novel therapeutic strategy targeting lumbar neural circuitry after spinal cord injury.

作者信息

Han Qi, Xu Xiao-Ming

机构信息

Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute; Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

出版信息

Neural Regen Res. 2020 Dec;15(12):2241-2242. doi: 10.4103/1673-5374.284985.

DOI:10.4103/1673-5374.284985
PMID:32594037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749477/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ee/7749477/02ca22b44962/NRR-15-2241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ee/7749477/02ca22b44962/NRR-15-2241-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ee/7749477/02ca22b44962/NRR-15-2241-g001.jpg

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本文引用的文献

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Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice.用于 NT-3 介导的脊髓损伤后运动功能恢复的下行运动通路。
Nat Commun. 2019 Dec 20;10(1):5815. doi: 10.1038/s41467-019-13854-3.
2
Moving beyond the glial scar for spinal cord repair.超越脊髓修复的神经胶质瘢痕。
Nat Commun. 2019 Aug 28;10(1):3879. doi: 10.1038/s41467-019-11707-7.
3
Targeted neurotechnology restores walking in humans with spinal cord injury.靶向神经技术恢复脊髓损伤患者的行走能力。
Oxid Med Cell Longev. 2024 Jun 20;2024:4293391. doi: 10.1155/2024/4293391. eCollection 2024.
4
Neurotrophins and neural stem cells in posttraumatic brain injury repair.创伤性脑损伤修复中的神经营养因子和神经干细胞。
Animal Model Exp Med. 2024 Feb;7(1):12-23. doi: 10.1002/ame2.12363. Epub 2023 Nov 29.
5
NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration.NT-3 与 TGF-β 信号通路联合抑制胶质瘢痕形成并促进轴突再生，增强脊髓损伤修复。
Mol Biotechnol. 2024 Jun;66(6):1484-1495. doi: 10.1007/s12033-023-00781-4. Epub 2023 Jun 15.
6
Fluoxetine, a selective serotonin reuptake inhibitor used clinically, improves bladder function in a mouse model of moderate spinal cord injury.氟西汀是一种临床上使用的选择性5-羟色胺再摄取抑制剂，可改善中度脊髓损伤小鼠模型的膀胱功能。
Neural Regen Res. 2021 Oct;16(10):2093-2098. doi: 10.4103/1673-5374.308667.
Nature. 2018 Nov;563(7729):65-71. doi: 10.1038/s41586-018-0649-2. Epub 2018 Oct 31.
4
Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery.胸段脊髓损伤后腰椎运动回路的重塑促进运动功能恢复。
Elife. 2018 Sep 12;7:e39016. doi: 10.7554/eLife.39016.
5
Recent progress and considerations for AAV gene therapies targeting the central nervous system.针对中枢神经系统的 AAV 基因治疗的最新进展和考虑因素。
J Neurodev Disord. 2018 May 18;10(1):16. doi: 10.1186/s11689-018-9234-0.
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Eur J Neurosci. 2010 Sep;32(6):997-1005. doi: 10.1111/j.1460-9568.2010.07392.x. Epub 2010 Sep 8.
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Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury.化学趋向性引导促进脊髓损伤后的轴突再生和突触形成。
Nat Neurosci. 2009 Sep;12(9):1106-13. doi: 10.1038/nn.2365. Epub 2009 Aug 2.
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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response.腺相关病毒介导的因子IX对血友病患者肝脏的成功转导及宿主免疫反应带来的限制
Nat Med. 2006 Mar;12(3):342-7. doi: 10.1038/nm1358. Epub 2006 Feb 12.