Kaushal Vishw, Kumar Sumir, Brar Balwinder Kaur, Singh Amarbir
Guru gobind Singh Medical College and Hospital, Faridkot, Punjab, India.
Dermatol Ther. 2020 Nov;33(6):e13919. doi: 10.1111/dth.13919. Epub 2020 Jul 29.
Management of keloid is difficult, so there is always a need for adequate and effective therapy. In this study, we explored and compared the efficacy and synergistic effect of combined intralesional radiofrequency (RF) and intralesional triamcinolone acetonide (TAC) with intralesional triamcinolone acetonide alone in the treatment of keloids. Sixty patients with keloid were divided in two groups of 30 patients each. In both groups total six sittings every 3 weeks and post treatment follow-up every 6 weeks was done. In group A, intralesional TAC was given. In group B, intralesional radiofrequency followed by triamcinolone was injected. In this study, there were 29 males and 31 females. In groups A and B, 73.4% and 80% of the patients, respectively, achieved grade 4 improvement at the end of 33 weeks, but there was greater mean POSAS score decline in group B in comparison with group A at each visit compared to baseline. Six patients in group A while three in group B showed recurrence. Side effects were equal in number in both groups Thus both the studied modalities of treatment produced equal efficacy and safety but with less recurrence in group B.
瘢痕疙瘩的治疗颇具难度，因此始终需要充分且有效的疗法。在本研究中，我们探究并比较了病灶内联合射频（RF）和曲安奈德（TAC）与单纯病灶内注射曲安奈德治疗瘢痕疙瘩的疗效及协同效应。60例瘢痕疙瘩患者被分为两组，每组30例。两组均每3周进行6次治疗，每6周进行一次治疗后随访。A组给予病灶内注射曲安奈德，B组先进行病灶内射频治疗，随后注射曲安奈德。本研究中，男性29例，女性31例。A组和B组分别有73.4%和80%的患者在33周结束时达到4级改善，但与基线相比，B组每次随访时的平均POSAS评分下降幅度均大于A组。A组有6例患者复发，B组有3例患者复发。两组的副作用数量相同。因此，两种研究的治疗方式产生了相同的疗效和安全性，但B组的复发率较低。
