Chou Tzu-Yun, Kuo Hsiao-Ping, Tsai Sheng-Fa, Huang Shyue-Tsong, Yang Meei-Ju, Lee Shoei-Sheng, Chang Chia-Chuan
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan R.O.C.
Bioresources Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan R.O.C.
Nat Prod Res. 2021 Dec;35(23):5459-5464. doi: 10.1080/14786419.2020.1781112. Epub 2020 Jun 27.
is a traditional Chinese medicine with various biological activities. With its limited natural supply, cultured has become the major alternative source, and the culture conditions may affect the chemical compositions. To improve the production of chemical ingredients, was cultured with three different media, including rice only, rice plus 3% tea leaves, and rice plus 3% droppings of . The fractions of dried cultured with rice were chromatographic separated to afford ten compounds: phenylalanine, dimerumic acid, nicotinic acid, tryptophan, -(2-hydroxyethyl)-adenosine, uracil, uridine, cordycepin, ergosterol, and mannitol. Of these, in the cultured medium of rice plus 3% droppings, the amount of one major compound cordycepin is about two folds than the highest reported data, and dimerumic acid and -(2-hydroxyethyl)-adenosine were isolated for the first time from this species.[Figure: see text].
是一种具有多种生物活性的传统中药。由于其天然供应有限，人工培养的已成为主要的替代来源，且培养条件可能会影响其化学成分。为提高化学成分的产量，用三种不同的培养基培养，包括仅大米、大米加3%茶叶以及大米加3%[某种生物]的粪便。用大米培养的干燥[该中药名称]的馏分经色谱分离得到十种化合物：苯丙氨酸、二聚麦角硫因、烟酸、色氨酸、β-(2-羟乙基)-腺苷、尿嘧啶、尿苷、虫草素、麦角甾醇和甘露醇。其中，在大米加3%[某种生物]粪便的培养基中，一种主要化合物虫草素的含量比报道的最高数据高出约两倍，并且首次从该物种中分离出二聚麦角硫因和β-(2-羟乙基)-腺苷。[图：见正文] （注：原文中部分关键信息未明确给出具体物种名称等，翻译可能存在一定模糊性）
