一名患有中枢神经系统结核病且初始检查结果为阴性的重症患者。

A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup.

作者信息

Zubair Adeel S, Landreneau Mark, Witsch Jens, Fulbright Robert K, Huttner Anita, Sheth Kevin N, Hwang David Y

机构信息

Department of Neurology, Yale School of Medicine, New Haven, CT, United States.

Department of Neurology, Stamford Hospital, Stamford, CT, United States.

出版信息

Front Neurol. 2020 Jun 12;11:430. doi: 10.3389/fneur.2020.00430. eCollection 2020.

DOI:10.3389/fneur.2020.00430

PMID:32595583

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7304250/

Abstract

Empiric anti-tuberculous therapy should not be delayed in patients with a strong clinical suspicion for TB. Because confirmatory TB testing may be difficult to obtain, early and empiric treatment, when there is concern for central nervous system TB, may result in improved outcomes for patients. GeneXpert is currently an area of active research, and the test returns diagnostic results within hours, which would make it the preferred test for investigating TB meningitis.

摘要

对于临床上高度怀疑患有结核病的患者，不应延迟经验性抗结核治疗。由于可能难以获得确诊结核病的检测结果，在怀疑有中枢神经系统结核时尽早进行经验性治疗，可能会改善患者的预后。GeneXpert目前是一个活跃的研究领域，该检测可在数小时内得出诊断结果，这使其成为调查结核性脑膜炎的首选检测方法。