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基于网络药理学的参芪复方治疗糖尿病机制的研究

Network Pharmacology-Based Identification of the Mechanisms of Shen-Qi Compound Formula in Treating Diabetes Mellitus.

作者信息

Hu Zhipeng, Yang Maoyi, Yang Liangjun, Xie Chunguang, Gao Hong, Fu Xiaoxu, Xie Hongyan, Liu Ya

机构信息

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.

出版信息

Evid Based Complement Alternat Med. 2020 Jun 4;2020:5798764. doi: 10.1155/2020/5798764. eCollection 2020.

DOI:10.1155/2020/5798764
PMID:32595730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7292981/
Abstract

AIM

The purpose of this research is to identify the mechanisms of Shen-Qi compound formula (SQC), a traditional Chinese medicine (TCM), for treating diabetes mellitus (DM) using system pharmacology.

METHODS

The active components and therapeutic targets were identified, and these targets were analyzed using gene ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and protein-protein interaction (PPI) analysis. Finally, an integrated pathway was constructed to show the mechanisms of SQC.

RESULTS

A total of 282 active components and 195 targets were identified through a database search. The component-target network was constructed, and the key components were screened out according to their degree. Through the GO, PPI, and KEGG analyses, the mechanism network of SQC treating DM was constructed.

CONCLUSIONS

This study shows that the mechanisms of SQC treating DM are related to various pathways and targets. This study provides a good foundation and basis for further in-depth verification and clinical application.

摘要

目的

本研究旨在运用系统药理学方法，阐明中药参芪复方（SQC）治疗糖尿病（DM）的作用机制。

方法

确定活性成分和治疗靶点，并利用基因本体论（GO）富集分析、京都基因与基因组百科全书（KEGG）富集分析和蛋白质-蛋白质相互作用（PPI）分析对这些靶点进行分析。最后构建整合通路以展示SQC的作用机制。

结果

通过数据库检索共鉴定出282种活性成分和195个靶点。构建了成分-靶点网络，并根据其度数筛选出关键成分。通过GO、PPI和KEGG分析，构建了SQC治疗DM的作用机制网络。

结论

本研究表明SQC治疗DM的机制与多种通路和靶点相关。本研究为进一步深入验证和临床应用提供了良好的基础和依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/ce4a0e833afd/ECAM2020-5798764.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/ce4a0e833afd/ECAM2020-5798764.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/fc9d4e7effeb/ECAM2020-5798764.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/11a7fdc9576d/ECAM2020-5798764.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/ba35d1f4f738/ECAM2020-5798764.003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/eae3c694e29c/ECAM2020-5798764.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/946a6497e28e/ECAM2020-5798764.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/3dc6b18de251/ECAM2020-5798764.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f467/7292981/ce4a0e833afd/ECAM2020-5798764.008.jpg

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2
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Drugs Context. 2020 Jan 27;9:212607. doi: 10.7573/dic.212607. eCollection 2020.
3
Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics.从 2 型糖尿病遗传学角度探讨胰岛细胞功能障碍。
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5
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Evid Based Complement Alternat Med. 2020 Dec 1;2020:6628641. doi: 10.1155/2020/6628641. eCollection 2020.
Nat Rev Endocrinol. 2020 Apr;16(4):202-212. doi: 10.1038/s41574-020-0325-0. Epub 2020 Feb 25.
4
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5
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