Chiang Hao, Lu Hsu-Feng, Chen Jui-Chieh, Chen Yu-Hsin, Sun Hsi-Tai, Huang Hsiu-Chen, Tien Hsiao-Hsuan, Huang Cheng
Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Departments of Clinical Pathology, Cheng Hsin General Hospital, Taipei 11221, Taiwan.
Evid Based Complement Alternat Med. 2020 May 29;2020:9519625. doi: 10.1155/2020/9519625. eCollection 2020.
Nonalcoholic fatty liver disease (NAFLD) is common worldwide and closely associated with metabolic dysfunction. NAFLD leads to a higher risk of development of severe liver diseases, such as nonalcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma (HCC). To date, no pharmacotherapy targeting NAFLD has received general approval. Adlay is a plant that has been used as traditional herbal medicine in Asia and is a promising candidate to solve this global issue. We have established a mouse model of NAFLD by feeding a high-fat diet (HFD) for 10 weeks. Here, ethanolic or water extracts of adlay seed (ASE and ASW, respectively), mixed with HFD, were fed to the mice for 10 weeks. The ASE and ASW treatment ameliorated hyperglycemia and improved the glucose tolerance and insulin resistance in the HFD mice. Hyperlipidemia in HFD mice was prevented by the ASE and ASW diet. In addition, the ASE and ASW supplementation attenuated hepatic steatosis and inflammation, improved liver function, and caused no harm to the kidneys. Moreover, the mechanism of the effect of ASE and ASW on inhibiting hepatic lipogenesis and inducing fatty acid -oxidation was certified by the simulated human fatty liver cell model. Our study showed the regulatory potential of the extracts of adlay seeds for alleviating NAFLD, as well as related liver and metabolic diseases.
非酒精性脂肪性肝病（NAFLD）在全球范围内普遍存在，且与代谢功能障碍密切相关。NAFLD会导致发展为严重肝脏疾病的风险增加，如非酒精性脂肪性肝炎（NASH）、肝硬化和肝细胞癌（HCC）。迄今为止，尚无针对NAFLD的药物疗法获得普遍认可。薏仁是一种在亚洲被用作传统草药的植物，是解决这一全球性问题的有潜力的候选者。我们通过给小鼠喂食高脂饮食（HFD）10周建立了NAFLD小鼠模型。在此，将薏仁种子的乙醇提取物或水提取物（分别为ASE和ASW）与HFD混合后，喂食小鼠10周。ASE和ASW处理改善了高血糖，并提高了HFD小鼠的葡萄糖耐量和胰岛素抵抗。ASE和ASW饮食预防了HFD小鼠的高脂血症。此外，补充ASE和ASW可减轻肝脏脂肪变性和炎症，改善肝功能，且对肾脏无损害。此外，通过模拟人类脂肪肝细胞模型证实了ASE和ASW抑制肝脏脂肪生成和诱导脂肪酸氧化作用的机制。我们的研究显示了薏仁种子提取物在缓解NAFLD以及相关肝脏和代谢疾病方面的调节潜力。
