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Cancer Med. 2017 Dec;6(12):2918-2931. doi: 10.1002/cam4.1221. Epub 2017 Oct 25.
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Use of acupuncture to alleviate side effects in radiation oncology: Current evidence and future directions.针刺疗法用于减轻放射肿瘤学中的副作用:当前证据与未来方向
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Biochem Pharmacol. 2017 Oct 1;141:132-142. doi: 10.1016/j.bcp.2017.04.029. Epub 2017 Apr 29.
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Eur J Cancer Care (Engl). 2017 Mar;26(2). doi: 10.1111/ecc.12633. Epub 2017 Jan 19.
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Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.头颈部鳞状细胞癌:流行病学、诊断和治疗的最新进展
Mayo Clin Proc. 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017.
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IL-10 cytokine released from M2 macrophages is crucial for analgesic and anti-inflammatory effects of acupuncture in a model of inflammatory muscle pain.在炎症性肌肉疼痛模型中,M2巨噬细胞释放的白细胞介素-10细胞因子对针灸的镇痛和抗炎作用至关重要。
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Transcutaneous auricular vagus nerve stimulation as a complementary therapy for pediatric epilepsy: a pilot trial.经皮耳迷走神经刺激作为儿童癫痫的补充疗法:一项初步试验。
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针刺疗法治疗放射性头颈癌伴味觉障碍

Acupuncture Therapy in Post-Radiation Head-and-Neck Cancer with Dysgeusia.

作者信息

Djaali Wahyuningsih, Simadibrata Christina Lanny, Nareswari Irma

机构信息

Universitas Negeri Jakarta, East Jakarta, Jakarta, Indonesia.

Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Jakarta, Indonesia.

出版信息

Med Acupunct. 2020 Jun 1;32(3):157-162. doi: 10.1089/acu.2020.1410. Epub 2020 Jun 16.

DOI:10.1089/acu.2020.1410
PMID:32595823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7310235/
Abstract

Radiation therapy for head-and-neck cancer can cause side-effects, including pain, nausea, vomiting, sensory disorders such as anosmia and dysgeusia, dysphagia, xerostomia, hot flashes, fatigue, sleep disorders, and even anxiety and depression disorders. Therapies using acupuncture are now being adopted at cancer therapy centers. Acupuncture has been clinically proven to reduce the side-effects of cancer therapies, thus, resulting in better quality of life. A 65-year-old man was diagnosed with stage I laryngeal squamous-cell carcinoma (SCC), and had missing taste and pain on swallowing (visual analogue scale [VAS]: 4) after undergoing 30 sessions of radiation therapy for head-and-neck cancer with a total radiation dose of 60 Gy. He received acupuncture at: body points (LI 4 , LR 3 , ST 36 , SP 6 , and ST 40 ); the Battlefield Acupuncture points of the ear (Cingulate Gyrus, Thalamus, Zero Point, , and Omega 2); and on the wrist area (according to a balance method). Acupuncture therapy was given 2 times a week, for 45-minute sessions. After 12 acupuncture sessions, he had improvement in taste function and pain reduction from VAS 4 to VAS 1. This improvement likely occurred due to acupuncture's anti-inflammatory effects through anti-inflammatory mediator secretion, an antipain effect through ß-endorphin secretion, and nerve-cell regeneration through neurotropic factors' secretion. Routine acupuncture therapy can reduce dysgeusia and pain in postradiated patients with head-and-neck cancer. Acupuncture can be a therapeutic choice for patients with post-radiation head-and-neck cancer toxicity.

摘要

头颈癌的放射治疗会引发副作用,包括疼痛、恶心、呕吐、嗅觉丧失和味觉障碍等感觉障碍、吞咽困难、口干、潮热、疲劳、睡眠障碍,甚至焦虑和抑郁障碍。目前癌症治疗中心正在采用针灸疗法。针灸已被临床证明可减轻癌症治疗的副作用,从而提高生活质量。一名65岁男性被诊断为I期喉鳞状细胞癌(SCC),在接受了30次头颈癌放射治疗,总放射剂量为60 Gy后,出现味觉丧失和吞咽疼痛(视觉模拟评分法[VAS]:4)。他接受了以下部位的针灸治疗:身体穴位(合谷穴、太冲穴、足三里穴、三阴交穴和丰隆穴);耳部战场穴位(扣带回、丘脑、零点和欧米伽2);以及手腕区域(根据平衡法)。针灸治疗每周进行2次,每次45分钟。经过12次针灸治疗后,他的味觉功能有所改善,疼痛从VAS 4降至VAS 1。这种改善可能是由于针灸通过分泌抗炎介质产生抗炎作用、通过分泌β-内啡肽产生止痛作用以及通过分泌神经营养因子促进神经细胞再生。常规针灸治疗可减轻头颈癌放疗后患者的味觉障碍和疼痛。对于放疗后出现头颈癌毒性反应的患者,针灸可以作为一种治疗选择。