Ting Xiao Wei, Sothiraghagan Shankari, W Md Kasim Wan Mariny, Muhammed Julieana
Ophthalmology, Universiti Sains Malaysia, Kelantan, MYS.
Ophthalmology, University Putra Malaysia, Putrajaya, MYS.
Cureus. 2020 May 24;12(5):e8259. doi: 10.7759/cureus.8259.
Objective To describe the patient demographics, clinical findings, investigations, surgical outcomes, and histopathological findings of seven cases of orbital solitary fibrous tumours. Method This was a retrospective review of seven cases of orbital solitary fibrous tumour, which were followed up in Hospital Serdang, a national oculoplastic centre, from years 2008-2017. Results This study included seven patients with ages between 21 and 35 years old; two were males and five were females. All seven patients presented with painless chronic unilateral proptosis. Radiological imaging of the orbit showed a localized contrast enhancing intraorbital mass. All patients underwent orbitotomy and excisional biopsy. Intraoperative findings showed a well-encapsulated and vascularized mass. Histological findings of spindle-shaped cells were noted. All cases had positive staining for cluster of differentiation (CD) 34, five were positive for CD 99, four were positive for B-cell lymphoma (BCL-2), and five patients had positive staining for S-100. Three of the patients did not have clear margins during the primary operation and subsequently had a recurrence within two years. Conclusion A solitary fibrous tumour is a rare mesenchymal tumour with a pleural origin. The orbit is the most common extrapleural site of the tumour and they are usually benign. Immunohistochemistry is important to differentiate it from other, more aggressive forms of orbital tumours. Regular follow-up is important to monitor for recurrence.
目的 描述7例眼眶孤立性纤维瘤患者的人口统计学特征、临床发现、检查、手术结果及组织病理学发现。方法 对2008年至2017年在国家眼整形中心——雪兰莪医院随访的7例眼眶孤立性纤维瘤病例进行回顾性研究。结果 本研究纳入7例年龄在21至35岁之间的患者；2例为男性，5例为女性。所有7例患者均表现为无痛性慢性单侧眼球突出。眼眶的影像学检查显示眶内有一个局限性强化肿块。所有患者均接受了眶切开术及切除活检。术中发现为一个包膜完整且血管丰富的肿块。可见梭形细胞的组织学表现。所有病例的分化簇（CD）34染色均为阳性，5例CD99染色阳性，4例B细胞淋巴瘤（BCL-2）染色阳性，5例患者S-100染色阳性。3例患者在初次手术时切缘不清晰，随后在两年内复发。结论 孤立性纤维瘤是一种罕见的起源于间叶组织的肿瘤。眼眶是该肿瘤最常见的胸膜外部位，且通常为良性。免疫组织化学对于将其与其他更具侵袭性的眼眶肿瘤形式相鉴别很重要。定期随访对于监测复发很重要。
