Tam Eric S, Chen Edmund C, Nijhawan Navdeep, Harvey John T, Howarth David, Oestreicher James H
St. Michael's Hospital, Department of Ophthalmology, University of Toronto, Toronto, Canada.
Orbit. 2008;27(6):426-31. doi: 10.1080/01676830802344508.
Solitary fibrous tumor (SFT) occurs rarely in the orbit. We present four such cases, representing one of the largest case series reported to date of this rare orbital tumor.
The four patients ranged from ages 20 to 50, all of whom presented with lid swelling or bulging in the involved eye. All four patients underwent CT scan to confirm the diagnosis of an orbital mass, which was then excised.
The tumors of all four specimens contained spindle-shaped cells with bland nuclei and rare mitotic figures. They all stained positively with CD34 and vimentin. Resection margins were positive in two of the four cases. One of these cases demonstrated residual tumor on follow-up CT scan, which remained unchanged at one-year follow-up. No evidence of residual tumor was found in the other three cases, despite one having malignant pathology.
SFT is a rare and generally benign tumor of the orbit. Immunohistochemical testing with CD34 is necessary to confirm the diagnosis. Although en bloc tumor resection is the definitive treatment, residual tumor may remain stable for some time. However, this must be followed closely if complete resection is not carried out.
孤立性纤维瘤（SFT）很少发生于眼眶。我们报告4例此类病例，是迄今为止报道的该罕见眼眶肿瘤最大病例系列之一。
4例患者年龄在20至50岁之间，均表现为患眼眼睑肿胀或突出。所有4例患者均接受CT扫描以确诊眼眶肿物，随后肿物被切除。
所有4个标本的肿瘤均含有核温和的梭形细胞，有丝分裂象罕见。它们均对CD34和波形蛋白呈阳性染色。4例中有2例手术切缘阳性。其中1例在随访CT扫描时显示有残留肿瘤，在1年随访中保持不变。另外3例未发现残留肿瘤证据，尽管其中1例病理为恶性。
SFT是一种罕见的眼眶肿瘤，通常为良性。需进行CD34免疫组化检测以确诊。尽管整块肿瘤切除是确定性治疗方法，但残留肿瘤可能在一段时间内保持稳定。然而，如果未进行完整切除，则必须密切随访。
