Department of Chemistry, University of California Davis, Davis, CA, USA.
Department of Chemistry, University of California Davis, Davis, CA, USA.
Curr Opin Chem Biol. 2020 Oct;58:121-136. doi: 10.1016/j.cbpa.2020.08.003. Epub 2020 Sep 11.
With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan-protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.
随着碳水化合物化学合成的不断进步，细菌糖组成为越来越有吸引力和可及的合成目标。尽管细菌也产生含有碳水化合物的次生代谢物，但我们在这里的综述将涵盖细菌表面聚糖的近期化学合成研究进展。所获得的化合物是开发改进的结构定义糖缀合物疫苗以对抗细菌感染的极好候选物。它们也是研究糖-蛋白相互作用的重要探针。本文重点介绍了在最近合成的几种细菌表面聚糖中形成一些具有挑战性的糖苷键的糖基化策略，这些糖苷键涉及各种不常见的糖。
