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接受化疗的乳腺癌患者延长表达性写作对健康结果的影响:一项多中心随机对照试验。

Effect of prolonged expressive writing on health outcomes in breast cancer patients receiving chemotherapy: a multicenter randomized controlled trial.

机构信息

Nanfang Hospital, Southern Medical University, NO.1838 North Guangzhou Avenue, Baiyun District, Guangzhou City, Guangdong Province, China.

Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People's Republic of China.

出版信息

Support Care Cancer. 2021 Feb;29(2):1091-1101. doi: 10.1007/s00520-020-05590-y. Epub 2020 Jun 30.

Abstract

PURPOSE

This study aims to evaluate the effects of prolonged expressive writing on health outcomes in breast cancer patients undergoing chemotherapy to help understand how the dosage of an expressive writing intervention might moderate its effects.

METHODS

A total of 112 breast cancer patients undergoing chemotherapy were randomly allocated to the expressive writing group (n = 56) or the prolonged expressive writing group (n = 56). The expressive writing group received the standard expressive writing intervention based on Pennebaker's prompt to write for at least 20 min over four consecutive days (4 sessions). The prolonged expressive writing group used a modified prompt: write for at least 20 min 3 times a week over a 4-week period (12 sessions); patients could choose whether to write on consecutive days or not. All participants were required to write about their stressor-related upsetting or traumatic feelings about breast cancer. Outcomes were assessed and compared at baseline, as well as 1 month, 3 months, and 6 months postintervention.

RESULTS

There was no significant difference in the patients' quality of life, or physical and psychological wellbeing between the expressive writing group and the prolonged expressive writing group at any time point (all p > .05). The quality of life of breast cancer patients significantly decreased in the two groups over time (F = 40.64, p < .001).

CONCLUSION

Our findings suggest that the writing dosage does not moderate the effects of expressive writing on breast cancer patients undergoing chemotherapy.

TRIAL REGISTRATION

ChiCTR1800016278.

摘要

目的

本研究旨在评估延长表达性写作对接受化疗的乳腺癌患者健康结果的影响,以帮助理解表达性写作干预的剂量如何调节其效果。

方法

共有 112 名接受化疗的乳腺癌患者被随机分配到表达性写作组(n=56)或延长表达性写作组(n=56)。表达性写作组接受基于彭尼贝克提示的标准表达性写作干预,即连续 4 天(4 次)每天至少写 20 分钟。延长表达性写作组使用修改后的提示:在 4 周内每周至少写 3 次,每次至少 20 分钟(12 次);患者可以选择是否连续几天写作。所有参与者都被要求写下与乳腺癌相关的压力、烦恼或创伤性感受。在干预前、干预后 1 个月、3 个月和 6 个月评估和比较结果。

结果

在任何时间点,表达性写作组和延长表达性写作组的患者生活质量、身体和心理健康状况均无显著差异(均 p>.05)。随着时间的推移,两组乳腺癌患者的生活质量均显著下降(F=40.64,p<.001)。

结论

我们的发现表明,写作剂量不会调节表达性写作对接受化疗的乳腺癌患者的影响。

试验注册

ChiCTR1800016278。

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