Department of Neurology, University of Virginia, P.O. Box 800432, Charlottesville, VA, 22908, USA.
Curr Neurol Neurosci Rep. 2020 Jun 29;20(8):33. doi: 10.1007/s11910-020-01054-2.
Patients with brain tumors are susceptible to multiple complications that can affect their survival or quality of life. The scope of these complications is widening due to prolonged overall survival and improved therapies. In this review, we discuss the most common complications in this patient population focusing on the recent literature. We specifically concentrated on tumor-related epilepsy, vasogenic edema, infectious, vascular, chemotherapeutic, radiation, endocrine, and cognitive complications.
Molecular biomarkers play a role in epileptogenicity in brain tumor patients, and anti-epileptic drugs may cause neuro-cognitive side effects independent of other factors. The pathophysiology of vasogenic edema remains complex and poorly understood. Limited data suggest that newer oral anticoagulants appear to be safe and effective in venous and arterial thromboembolic complications. Brain tumor patients are prone to a wide variety of complications, including some related to new therapies. Optimal management of these complications improves quality of life, and in some cases overall survival.
脑肿瘤患者易发生多种并发症，这些并发症可能会影响他们的生存或生活质量。由于整体生存率的提高和治疗方法的改善，这些并发症的范围正在扩大。在本次综述中，我们讨论了该患者群体中最常见的并发症，重点关注最新文献。我们特别关注与肿瘤相关的癫痫、血管源性水肿、感染、血管、化疗、放疗、内分泌和认知并发症。
分子生物标志物在脑肿瘤患者的致痫性中发挥作用，抗癫痫药物可能会导致神经认知副作用，而与其他因素无关。血管源性水肿的病理生理学仍然很复杂，也不太清楚。有限的数据表明，新型口服抗凝剂在静脉和动脉血栓栓塞并发症方面似乎是安全有效的。脑肿瘤患者易发生多种并发症，包括与新疗法相关的一些并发症。这些并发症的最佳管理可以提高生活质量，在某些情况下还可以提高整体生存率。
