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定制生物墨水的组织模型 3D 生物打印

3D Bioprinting of Tissue Models with Customized Bioinks.

机构信息

Biovalda Health Technologies, Inc., Ankara, Turkey.

Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Ankara University Faculty of Science, Ankara, Turkey.

出版信息

Adv Exp Med Biol. 2020;1249:67-84. doi: 10.1007/978-981-15-3258-0_5.

Abstract

The ordered assembly of multicellular structures mimicking native tissues has lately come into prominence for various applications of biomedicine. In this respect, three-dimensional bioprinting (3DP) of cells and other biologics through additive manufacturing techniques has brought the possibility to develop functional in vitro tissue models and perhaps creating de novo transplantable tissues or organs in time. Bioinks, which can be defined as the printable analogues of the extracellular matrix, represent the foremost component of 3DP. In this chapter, we attempt to elaborate the major classes of bioinks which are prevalently being evaluated for the 3DP of a wide range of tissue models.

摘要

最近,为了满足生物医学的各种应用需求,模仿天然组织的多细胞结构的有序组装受到了广泛关注。在这方面,通过增材制造技术对细胞和其他生物材料进行三维生物打印(3DP),为开发功能性体外组织模型并及时构建新的可移植组织或器官提供了可能。生物墨水可以被定义为细胞外基质的可打印类似物,是 3DP 的最主要组成部分。在本章中,我们试图详细介绍目前广泛用于 3DP 各种组织模型的主要生物墨水类别。

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