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用于组织工程和药物输送的可见光固化水凝胶系统。

Visible Light-Curable Hydrogel Systems for Tissue Engineering and Drug Delivery.

机构信息

Institute of Cell & Tissue Engineering and College of Medicine, Catholic University of Korea, Seoul, South Korea.

出版信息

Adv Exp Med Biol. 2020;1249:85-93. doi: 10.1007/978-981-15-3258-0_6.

Abstract

Visible light-curable hydrogels have been investigated as tissue engineering scaffolds and drug delivery carriers due to their physicochemical and biological properties such as porosity, reservoirs for drugs/growth factors, and similarity to living tissue. The physical properties of hydrogels used in biomedical applications can be controlled by polymer concentration, cross-linking density, and light irradiation time. The aim of this review chapter is to outline the results of previous research on visible light-curable hydrogel systems. In the first section, we will introduce photo-initiators and mechanisms for visible light curing. In the next section, hydrogel applications as drug delivery carriers will be emphasized. Finally, cellular interactions and applications in tissue engineering will be discussed.

摘要

可见光固化水凝胶因其多孔性、药物/生长因子储库以及与活组织相似等理化和生物学特性,已被研究作为组织工程支架和药物输送载体。用于生物医学应用的水凝胶的物理性质可以通过聚合物浓度、交联密度和光照射时间来控制。本章综述的目的是概述可见光固化水凝胶系统的先前研究结果。在第一节中,我们将介绍光引发剂和可见光固化机制。在下一节中,将重点介绍水凝胶作为药物输送载体的应用。最后,将讨论细胞相互作用和在组织工程中的应用。

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