Department of fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Nanjing Medical University, Nanjing, China.
Climacteric. 2021 Apr;24(2):146-150. doi: 10.1080/13697137.2020.1776249. Epub 2020 Jun 30.
Inflammatory diseases are risk factors for osteoporosis. We aimed to explore whether fibrinogen, which is linked to chronic inflammation, is associated with bone mineral density (BMD) in menopausal women.
In this cross-sectional study, we analyzed 339 menopausal women from Zhejiang Province between January 2016 and October 2019. Linear regression analysis was performed to assess the relationship between fibrinogen and BMD.
Significant inverse association was observed between the serum fibrinogen level and BMD in menopausal women. The mean BMD in each quartile of fibrinogen level was 0.901, 0.897, 0.892, and 0.855 g/cm, respectively ( = 0.027). After adjusting for age, body mass index, metabolic profiles, blood inflammatory factors, and serum levels of estradiol, calcium, phosphorus, and alkaline phosphatase, fibrinogen levels remained significantly associated with BMD (regression coefficients for quartiles 1-3 vs. quartile 4 were 0.046, 0.027, and 0.036, respectively; for trend <0.05).
Higher fibrinogen levels were associated with lower BMD in menopausal women, which was independent of age, body mass index, estradiol, and other factors. Therefore, serum fibrinogen can be used as a new predictor of reduced BMD in menopausal women.
炎症性疾病是骨质疏松症的危险因素。我们旨在探讨与慢性炎症相关的纤维蛋白原是否与绝经后妇女的骨密度（BMD）有关。
在这项横断面研究中，我们分析了 2016 年 1 月至 2019 年 10 月期间来自浙江省的 339 名绝经后妇女。进行线性回归分析以评估纤维蛋白原与 BMD 之间的关系。
在绝经后妇女中，血清纤维蛋白原水平与 BMD 呈显著负相关。纤维蛋白原水平每个四分位数的平均 BMD 分别为 0.901、0.897、0.892 和 0.855 g/cm（ = 0.027）。在校正年龄、体重指数、代谢谱、血液炎症因子以及雌二醇、钙、磷和碱性磷酸酶的血清水平后，纤维蛋白原水平仍与 BMD 显著相关（四分位数 1-3 与四分位数 4 的回归系数分别为 0.046、0.027 和 0.036；趋势<0.05）。
较高的纤维蛋白原水平与绝经后妇女的较低 BMD 相关，这与年龄、体重指数、雌二醇和其他因素无关。因此，血清纤维蛋白原可用作绝经后妇女 BMD 降低的新预测指标。
