Department of Obstetrics and Gynecology, Nanjing Medical University, Nanjing, China.
Department of the Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Gynecol Endocrinol. 2021 Jul;37(7):650-654. doi: 10.1080/09513590.2021.1885642. Epub 2021 Feb 16.
The aim of the present study was to investigate whether systemic immune-inflammation index (SII) and neutrophil-to-platelet ratio (NLR) were associated with bone mineral density (BMD) in postmenopausal women.
In this cross-sectional study, we enrolled 413 postmenopausal women who never received menopause hormone therapy. The relationship between SII, NLR, and BMD was investigated by linear regression analysis.
Significant inverse association was observed between SII and BMD in postmenopausal women. The mean BMD in each quartile of SII level were 0.923, 0.914, 0.900, and 0.876 g/cm, respectively ( = .011). After adjusting for covariates, SII levels remained significantly associated with BMD (regression coefficients for quartiles 1-3 vs. quartile 4 were 0.035, 0.029, and 0.023, respectively; for trend <.05). An inverse association was also found between NLR and BMD in postmenopausal women. However, there was no significant association between NLR and BMD after adjusting for covariates.
The quartile of SII was negatively associated with the mean BMD in postmenopausal women, independent of age, body mass index, sex hormone levels, and other factors. Therefore, SII can be used as a new predictor of bone loss in postmenopausal women.
本研究旨在探讨全身免疫炎症指数（SII）和中性粒细胞与血小板比值（NLR）是否与绝经后妇女的骨密度（BMD）相关。
在这项横断面研究中，我们纳入了 413 名从未接受过绝经激素治疗的绝经后妇女。通过线性回归分析研究了 SII、NLR 与 BMD 之间的关系。
在绝经后妇女中，SII 与 BMD 呈显著负相关。SII 水平每增加一个四分位，BMD 的平均值分别为 0.923、0.914、0.900 和 0.876 g/cm，差异有统计学意义（ = .011）。在校正了混杂因素后，SII 水平与 BMD 仍呈显著相关（四分位 1-3 与四分位 4 的回归系数分别为 0.035、0.029 和 0.023，趋势 <.05）。NLR 与 BMD 也呈负相关，但在校正了混杂因素后，NLR 与 BMD 之间无显著相关性。
SII 四分位数与绝经后妇女的平均 BMD 呈负相关，独立于年龄、体重指数、性激素水平和其他因素。因此，SII 可作为绝经后妇女骨丢失的新预测指标。
