PAFS Research Group (Physical Activity and Health Promotion Research Group), Universidad de Castilla-La Mancha, Toledo, Spain.
CIBERFES Research Group (Centro de Investigación Biomédica en Red. Fragilidad y Envejecimiento Saludable), Madrid, Spain.
Climacteric. 2021 Feb;24(1):89-94. doi: 10.1080/13697137.2020.1776248. Epub 2020 Jun 30.
As the population is getting older, physical activity promotion becomes a good strategy to increase quality of life in the elderly; but genetic condition also plays an important role. The purpose of this study was to examine the association of the ACTN3 R577X polymorphism with physical fitness and muscle mass in physically active older women.
A cross-sectional study was performed with two groups of older women who practiced physical exercise regularly. The first cohort comprised 164 women (age 69.7 ± 3.2 years) and the second cohort 131 women (age 78.5 ± 3.0 years). The main outcome measures were anthropometric measures with assessment of sarcopenia and sarcopenic obesity, self-reported physical activity EXERNET questionnaire (EEPAQ), evaluation of physical fitness (muscle strength and flexibility test), and ACTN3 genotyping.
Women above 75 years old with allele R presented a higher risk of experiencing sarcopenia compared to ACTNR XX homozygous women (odds ratio 0.356, 95% confidence interval 0.139-0.915, = 0.026). Furthermore, statistically significant differences were found in the chair stand test ( = 0.04), as well as in the sit and reach test ( = 0.01), with better results for women below 75 years old with the ACTN3 XX genotype.
Sarcopenia and physical fitness show differences based on the ACTN3 R577X genotype in active older women.
随着人口老龄化，促进身体活动成为提高老年人生活质量的一个好策略；但遗传条件也起着重要作用。本研究的目的是探讨 ACTN3 R577X 多态性与活跃老年女性身体机能和肌肉质量的关系。
这是一项横断面研究，纳入了两组经常进行体育锻炼的老年女性。第一组包括 164 名女性（年龄 69.7±3.2 岁），第二组包括 131 名女性（年龄 78.5±3.0 岁）。主要观察指标为评估肌肉减少症和肌肉减少性肥胖的人体测量指标、自我报告的 EXERNET 问卷（EEPAQ）体力活动、身体机能评估（肌肉力量和柔韧性测试）以及 ACTN3 基因分型。
75 岁以上携带 R 等位基因的女性发生肌肉减少症的风险高于 ACTNR XX 纯合女性（比值比 0.356，95%置信区间 0.139-0.915， = 0.026）。此外，在椅子站立测试（ = 0.04）和坐立前伸测试（ = 0.01）中也发现了统计学上的显著差异，75 岁以下携带 ACTN3 XX 基因型的女性的测试结果更好。
在活跃的老年女性中，根据 ACTN3 R577X 基因型，肌肉减少症和身体机能存在差异。
