Graduate Program in Animal Science, Universidade Do Estado De Santa Catarina (UDESC) , Chapecó, Brazil.
Department of Animal Science, UDESC , Chapecó, Brazil.
Arch Anim Nutr. 2020 Oct;74(5):397-413. doi: 10.1080/1745039X.2020.1769442. Epub 2020 Jun 30.
The objectives of this study were to produce dog food containing curcumin replacing synthetic antioxidants, to evaluate its beneficial effects on animal growth and health. Curcumin (100 mg/kg) was added after the extrusion process along with the other micronutrients. The final concentration of curcumin was 32.9 mg/kg. The control feed was composed of the same ingredients without curcumin. After a storage of 6 months, feed composition and pH did not differ; however, the feed with curcumin showed lower protein oxidation, lipid peroxidation and higher total antioxidant capacity. After 2 months of feed production, 12 young Beagle dogs received either curcumin-containing food (n = 6) or the control diet (n = 6). The animals were fed twice a day using individual kennels. Blood samples were taken on d 1, 35 and 42. During the first 30 d of the study, the animals had natural infectious diseases that were controlled with anti-protozoals and antibiotics. Greater numbers of red blood cells were observed in dogs fed with curcumin (d 35 and 45), and there were greater numbers of white blood cells as a consequence of increased neutrophils on d 42. At the end of the experiment, a significant reduction in the number of lymphocytes was observed in dogs that ingested curcumin (d 42), suggesting an anti-inflammatory effect, manifested as a decrease in globulin levels. In the final 15 d of the experiment, the animals were clinical healthy. Higher serum levels of glucose, urea, triglycerides and cholesterol were observed in dogs fed with curcumin. Curcumin increased the activity of several antioxidant enzymes in addition to non-protein thiols and the total antioxidant capacity in the serum, consequently reducing levels of oxygen reactive species. Curcumin supplementation of dogs did not favour growth or weight gain. Neverthless, it was concluded that curcumin improved animal health, with emphasis on the stimulation of the antioxidant system and evidence of an anti-inflammatory effect.
本研究的目的是生产含有姜黄素的犬粮，以替代合成抗氧化剂，并评估其对动物生长和健康的有益影响。姜黄素（100mg/kg）在挤压过程后与其他微量营养素一起添加。最终姜黄素的浓度为 32.9mg/kg。对照饲料由不含姜黄素的相同成分组成。储存 6 个月后，饲料成分和 pH 值没有差异；然而，含有姜黄素的饲料显示出较低的蛋白质氧化、脂质过氧化和较高的总抗氧化能力。在饲料生产 2 个月后，12 只年轻的比格犬分别接受含有姜黄素的食物（n=6）或对照饮食（n=6）。动物每天用单独的犬舍喂食两次。在第 1、35 和 42 天采集血液样本。在研究的前 30 天，动物患有自然传染病，用抗原生动物药和抗生素进行了控制。用姜黄素喂养的狗的红细胞数量增加（第 35 和 45 天），并且由于第 42 天中性粒细胞增加，白细胞数量增加。实验结束时，发现摄入姜黄素的狗的淋巴细胞数量显著减少（第 42 天），表明有抗炎作用，表现为球蛋白水平降低。在实验的最后 15 天，动物临床健康。用姜黄素喂养的狗的血清葡萄糖、尿素、甘油三酯和胆固醇水平升高。姜黄素除了增加非蛋白巯基和血清总抗氧化能力外，还增加了几种抗氧化酶的活性，从而降低了活性氧物质的水平。姜黄素补充剂对狗的生长或体重增加没有好处。尽管如此，研究结论认为，姜黄素改善了动物的健康，特别是刺激了抗氧化系统，并证实了抗炎作用。
