Saluja Manoj, Pillai Drishya, Jeliya Shivcharan, Bauddh Nitesh, Chandel Rahul
Senior Professor, Department of Medicine, Government Medical College, Kota, Rajasthan.
PG Resident, Department of Medicine, Government Medical College, Kota, Rajasthan.
J Assoc Physicians India. 2020 Jul;68(7):13-18.
Since December 2019, we have been facing one of the worst pandemics of human history. It originated from the Hubei province in China as a case of pneumonia, later named COVID-19.1 The causative pathogen, a new enveloped betacoronavirus2 is now known as Severe acute respiratory syndrome corona virus-2 (SARS-CoV 2). India reported its first case of COVID19, on 30th January 2020. We aim to identify the defining clinical and radiological characteristics, severity and prognosis, along with impact of age on outcome.
Cross sectional, observational study of patients diagnosed with COVID -19 [RT-PCR].
We observed male predominance, mean age of 36 years, with less or no symptoms, majority brought in after screening and contact tracing by the screening teams. Thrombocytopenia, lymphocytosis, raised LDH was common (>35%, p<0.05). Patients over the age of 60 were the ones having severe illness and more complications (p<0.05). Radiographic abnormality was frequently associated irrespective of clinical presentation and its severity. Poor prognosis was noted in elderly, especially those with co-morbidities.
Though the disease has a relatively mild course in this part of the subcontinent, patients aged ≥60 are at significant risk for morbidity and mortality. Clinical and laboratory findings are similar to those found in viral diseases. Increased risk of cardiac involvement needs to be looked into. Chest X-ray proves sufficient for imaging, reducing the requirement of CT scans. Studies involving larger sample size and interventional trials are need of the hour.
自2019年12月以来，我们一直面临着人类历史上最严重的大流行之一。它起源于中国湖北省，最初表现为肺炎病例，后来被命名为COVID-19。1其致病病原体，一种新的有包膜的β冠状病毒2现在被称为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。印度于2020年1月30日报告了首例COVID-19病例。我们旨在确定其明确的临床和放射学特征、严重程度和预后，以及年龄对预后的影响。
对诊断为COVID-19[逆转录聚合酶链反应]的患者进行横断面观察性研究。
我们观察到男性占主导，平均年龄为36岁，症状较少或无症状，大多数患者是在筛查团队进行筛查和接触者追踪后被送来的。血小板减少、淋巴细胞增多、乳酸脱氢酶升高很常见（>35%，p<0.05）。60岁以上的患者患有严重疾病且并发症更多（p<0.05）。无论临床表现及其严重程度如何，影像学异常都经常出现。老年人，尤其是那些有合并症的患者预后较差。
尽管在该次大陆的这一地区该疾病病程相对较轻，但60岁及以上的患者有较高的发病和死亡风险。临床和实验室检查结果与病毒性疾病相似。需要进一步研究心脏受累风险增加的情况。胸部X光检查足以进行成像，减少了CT扫描的需求。目前需要开展涉及更大样本量的研究和干预试验。
