Exosome-transmitted long non-coding RNA suppresses the progression of hepatocellular carcinoma.

Extracellular communication mediated by exosomes in a tumor microenvironment can substantially affect tumor progression. However, the effect of exosomal long non-coding RNA on hepatocellular carcinoma (HCC) is still unclear. In this study, expressions in patients with HCC and healthy controls were detected and compared. Results showed that was significantly reduced in HCC tissues and exosomes from the plasma of patients with HCC (<0.05) and was primarily encapsulated by exosomes. The patients with HCC and the healthy controls could be distinguished using exosomal (AUC=0.8028). The transfer of exosomal secreted by normal cells to HCC cells stimulated apoptosis and weakened the invasion and migration abilities of HCC cells to suppress their malignant biological behavior (<0.05). Additionally, exosomal was capable of inhibiting tumor growth in vivo and modulating the expression of by competitively binding to miR-9-5p. In conclusion, exosomal is a new favorable biomarker for clinically detecting HCC, and can be transmitted by exosomes from normal cells to HCC cells to inhibit the and development of HCC. Thus, exosomal is involved in the communication between normal cells and HCC cells during the onset of HCC.