Department of Medicine, Division of Cardiology, New York-Presbyterian/Columbia University Irving Medical Center, New York, New York 10032.
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale New Haven Hospital, New Haven, Connecticut 06510.
Tex Heart Inst J. 2020 Apr 1;47(2):152-154. doi: 10.14503/THIJ-17-6586.
Zinc, an essential micronutrient, affects the heart by modulating cardiomyocyte oxidative stress and maintaining myocardial structure, among other mechanisms. In cross-sectional studies, patients with heart failure have often had zinc deficiencies, suggesting effects on the ongoing pathogenesis of heart failure. Low plasma and myocardial zinc levels may cause reversible cardiomyopathy in patients who have nutritional deficiencies. We present the case of a 24-year-old woman with anorexia nervosa and new-onset heart failure whose depressed left ventricular systolic function improved after zinc supplementation. To our knowledge, this is the first report of low plasma zinc levels as the chief cause of cardiomyopathy that resolved after zinc supplementation.
锌是一种必需的微量元素，通过调节心肌细胞氧化应激和维持心肌结构等机制影响心脏。在横断面研究中，心力衰竭患者往往存在锌缺乏，提示锌对心力衰竭的持续发病机制有影响。低血浆和心肌锌水平可能导致营养缺乏的患者发生可逆性心肌病。我们报告了一例 24 岁厌食症和新发心力衰竭女性患者的病例，在补锌后其左心室收缩功能减退得到改善。据我们所知，这是首例报道低血浆锌水平是导致心肌病的主要原因，补锌后可得到缓解。
