心肌梗死患者的血清锌浓度：一项回顾性研究。
Serum zinc concentration in patients with myocardial infarction: a retrospective study.
机构信息
Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.
出版信息
BMC Cardiovasc Disord. 2024 Feb 14;24(1):107. doi: 10.1186/s12872-024-03776-4.
BACKGROUND
Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction.
METHODS
Patients with myocardial infarction (n = 243) were divided using the median value of zinc concentration on admission into low (< 66 µg/dL at admission, n = 111) and high zinc group (≥ 66 µg/dL at admission, n = 132). During follow-up (mean ± SD: 734 ± 597 days; median 691 days), admission due to heart failure was observed in 12 patients: 10 and 2 cases in the low and high zinc groups, respectively.
RESULTS
The risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.0043). Relative to the high zinc group, the hazard ratio for admission due to heart failure was 15.7 (95% confidence interval 1.11-221, P = 0.042) via adjusted Cox proportional hazards analysis. Even after propensity score matching, the risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.048).
CONCLUSION
Low serum zinc concentration may be a risk factor for admission due to heart failure after myocardial infarction.
背景
锌可调节氧化应激和炎症信号级联反应，影响心血管疾病的发生和发展。我们研究了心肌梗死后发生心力衰竭的患者的预后。
方法
根据入院时锌浓度的中位数，将 243 例心肌梗死患者分为低锌组（入院时锌浓度<66μg/dL，n=111）和高锌组（入院时锌浓度≥66μg/dL，n=132）。在随访期间（平均±标准差：734±597 天；中位数 691 天），12 例患者因心力衰竭入院：低锌组和高锌组各有 10 例和 2 例。
结果
低锌组因心力衰竭入院的风险显著高于高锌组（P=0.0043）。通过调整后的 Cox 比例风险分析，与高锌组相比，低锌组因心力衰竭入院的风险比为 15.7（95%置信区间 1.11-221，P=0.042）。即使在进行倾向评分匹配后，低锌组因心力衰竭入院的风险仍显著高于高锌组（P=0.048）。
结论
血清锌浓度低可能是心肌梗死后心力衰竭入院的危险因素。
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