Namba H, Yanagisawa M, Yui N, Togawa T, Kinoshita F, Iwadate Y, Sueyoshi K
Division of Neurological Surgery, Chiba Cancer Center Hospital, Japan.
Ann Nucl Med. 1996 Feb;10(1):161-4. doi: 10.1007/BF03165072.
Regional cerebral blood flow was quantitatively measured in 6 patients with brain tumor by the microsphere model with N-isopropyl-p-[123I]iodoamphetamine (IMP) "super-early" single photon emission computed tomography (SPECT) images obtained 4-6 min after IMP injection with a three-head rotating gamma camera. The ratio of radioactivities (counts/pixel/min) in the "early" SPECT images (taken 25-55 min after IMP injection) to the "super-early" images of the brain tumors was 1.47 +/- 0.13 (mean +/- SD, n = 6), which was significantly lower than the ratio in the normal cerebral cortices (1.93 +/- 0.25) (p < 0.01). This indicates faster clearance of IMP from the tumor tissue than that from the normal brain tissue. Blood flow values for the brain tumors obtained by the microsphere model based on the "super-early" SPECT images were 39.3 +/- 12.4 ml/100 g/ min, which was similar to the blood flow values for normal gray matter and in agreement with previous studies with positron emission tomography.
采用微球模型，通过三头旋转γ相机，在注射N-异丙基-p-[123I]碘安非他明（IMP）后4 - 6分钟获得的“超早期”单光子发射计算机断层扫描（SPECT）图像，对6例脑肿瘤患者的局部脑血流量进行了定量测量。在“早期”SPECT图像（IMP注射后25 - 55分钟采集）中脑肿瘤的放射性活度（计数/像素/分钟）与“超早期”图像的放射性活度之比为1.47±0.13（均值±标准差，n = 6），显著低于正常大脑皮质的比值（1.93±0.25）（p < 0.01）。这表明IMP从肿瘤组织中的清除速度比从正常脑组织中更快。基于“超早期”SPECT图像通过微球模型获得的脑肿瘤血流量值为39.3±12.4 ml/100 g/分钟，这与正常灰质的血流量值相似，并且与先前正电子发射断层扫描的研究结果一致。
