Nisijima K, Matoba M, Ishiguro T
Department of Psychiatry, Jichi Medical School, Tochigi-Ken, Japan.
Neuroradiology. 1994 May;36(4):281-4. doi: 10.1007/BF00593260.
Single photon emission computed tomography (SPECT) perfusion brain scans using 123I-N-isopropyl-p-iodoamphetamine (123I-IMP) were performed in three patients with the neuroleptic malignant syndrome (NMS). In two accumulation was increased in the left basal ganglia and decreased in the right on the early images during the active phase of NMS; this asymmetry was not seen after recovery. In the third patient two examinations were performed during the active phase; on the first, increased accumulation of 123I-IMP in the left basal ganglia was found on the early images, but on the second, increased accumulation of tracer was found in the right basal ganglia on the delayed images. These abnormalities disappeared after improvement of the NMS. These results suggest that a disturbance in the basal ganglia is related to the development of NMS.
对3例患有抗精神病药恶性综合征（NMS）的患者进行了使用123I-N-异丙基-p-碘安非他明（123I-IMP）的单光子发射计算机断层扫描（SPECT）脑灌注扫描。在NMS活动期的早期图像上，2例患者左侧基底神经节放射性摄取增加，右侧减少；恢复后未发现这种不对称性。第3例患者在活动期进行了2次检查；第一次检查时，早期图像上发现左侧基底神经节123I-IMP摄取增加，但第二次检查时，延迟图像上发现右侧基底神经节放射性示踪剂摄取增加。NMS改善后，这些异常消失。这些结果表明，基底神经节功能紊乱与NMS的发生有关。
