Lakomek H J, Wagener S, Schwochau M, Krüskemper H L
Medizinische Klinik und Poliklinik C, Universität Düsseldorf.
Z Rheumatol. 1988 Mar-Apr;47(2):86-92.
Ha(La)-antibodies are detected by counterimmunoelectrophoresis (CIE) in sera of systemic lupus erythematosus (SLE) patients, but not in sera of patients with progressive systemic scleroderma (PSS) (n = 38), rheumatoid arthritis (n = 91), ankylosing spondylitis (n = 97), and other rheumatic diseases (n = 452). This antibody specificity was found in 27 out of 103 SLE patients (26%). However, 50% of SLE patients with Sjögren's syndrome (n = 12) showed the Ha(La)-antibody, suggesting a strong association in this clinical subgroup. Thus the Ha(La)-antibody can serve as a serological marker and helpful diagnostic tool for SLE. Additionally, the Ha(La)-antibody reacts with specific puffs in polytene chromosome preparations of Drosophila melanogaster. Therefore, this heterologous antigen system is suitable for the identification of Ha(La) sera.
通过对流免疫电泳（CIE）在系统性红斑狼疮（SLE）患者血清中检测到Ha（La）抗体，但在进行性系统性硬化症（PSS）患者（n = 38）、类风湿性关节炎（n = 91）、强直性脊柱炎（n = 97）和其他风湿性疾病患者（n = 452）的血清中未检测到。在103例SLE患者中有27例（26%）发现了这种抗体特异性。然而，50%的伴有干燥综合征的SLE患者（n = 12）显示出Ha（La）抗体，表明在这一临床亚组中有很强的关联性。因此，Ha（La）抗体可作为SLE的血清学标志物和有用的诊断工具。此外，Ha（La）抗体与黑腹果蝇多线染色体制备物中的特定疏松区发生反应。因此，这种异源抗原系统适用于鉴定含有Ha（La）的血清。
