Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania.
Institute of Interdisciplinary Research-CERNESIM Center, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, 700506 Iasi, Romania.
Molecules. 2020 Jun 26;25(12):2946. doi: 10.3390/molecules25122946.
Two new series of hybrid quinoline-sulfonamide complexes (M: Zn, Cu, Co and Cd) derivatives () were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu, Co and Cd) or chloride (Zn). The synthesized compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid -(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity against (with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 × 10 mg/mL), a very good antibacterial activity against (with a diameters of inhibition zones of 19 mm and a MIC of 609 × 10 mg/mL), and again an excellent antifungal activity against (with a diameters of inhibition zones of 25 mm and a MIC of 19.04 × 10 mg/mL).
设计、合成了两个新系列的混合喹啉-磺胺类配合物（M：Zn、Cu、Co 和 Cd）衍生物（），并测试了它们的抗菌活性。合成方法简单高效，包括两步：氨基喹啉的酰化反应，然后与金属醋酸盐（Cu、Co 和 Cd）或氯化物（Zn）络合。通过傅里叶变换红外光谱（FTIR）、核磁共振光谱（NMR）和单晶 X 射线衍射对合成的化合物进行了表征。对化合物进行了初步的抗菌和抗真菌活性筛选，结果非常有前景。在这方面，被认为是进一步研究的主导结构的混合-（8-喹啉基）-4-氯苯磺酰胺镉（II）对具有极好的抗菌活性（抑菌圈直径为 21mm，最小抑菌浓度（MIC）为 19.04×10mg/mL），对具有极好的抗菌活性（抑菌圈直径为 19mm，MIC 为 609×10mg/mL），对又具有极好的抗真菌活性（抑菌圈直径为 25mm，MIC 为 19.04×10mg/mL）。
