• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

组学方法在青霉素生产中的应用：揭示提高生产力的秘密。

Omics Approaches Applied to and Penicillin Production: Revealing the Secrets of Improved Productivity.

机构信息

INBIOTEC (Instituto de Biotecnología de León). Avda. Real 1-Parque Científico de León, 24006 León, Spain.

Departamento de Ciencias Biomédicas, Universidad de León, Campus de Vegazana s/n, 24071 León, Spain.

出版信息

Genes (Basel). 2020 Jun 26;11(6):712. doi: 10.3390/genes11060712.

DOI:10.3390/genes11060712
PMID:32604893
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7348727/
Abstract

Penicillin biosynthesis by is one of the best-characterized biological processes from the genetic, molecular, biochemical, and subcellular points of view. Several omics studies have been carried out in this filamentous fungus during the last decade, which have contributed to gathering a deep knowledge about the molecular mechanisms underlying improved productivity in industrial strains. The information provided by these studies is extremely useful for enhancing the production of penicillin or other bioactive secondary metabolites by means of Biotechnology or Synthetic Biology.

摘要

从遗传、分子、生化和亚细胞的角度来看，青霉素的生物合成是研究最透彻的生物学过程之一。在过去的十年中，人们对这种丝状真菌进行了几项组学研究，这些研究有助于深入了解提高工业菌株生产力的分子机制。这些研究提供的信息对于通过生物技术或合成生物学来提高青霉素或其他生物活性次生代谢产物的产量非常有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/806bc724ae09/genes-11-00712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/0f50e53a9f72/genes-11-00712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/9ac05a4dfaec/genes-11-00712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/52464e1c085a/genes-11-00712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/b96e1fc977d5/genes-11-00712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/806bc724ae09/genes-11-00712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/0f50e53a9f72/genes-11-00712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/9ac05a4dfaec/genes-11-00712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/52464e1c085a/genes-11-00712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/b96e1fc977d5/genes-11-00712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c82/7348727/806bc724ae09/genes-11-00712-g005.jpg

相似文献

1
Omics Approaches Applied to and Penicillin Production: Revealing the Secrets of Improved Productivity.组学方法在青霉素生产中的应用：揭示提高生产力的秘密。
Genes (Basel). 2020 Jun 26;11(6):712. doi: 10.3390/genes11060712.
2
Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.拉埃A和天鹅绒复合体蛋白在产黄青霉β-内酰胺和PR毒素基因表达中的关键作用：次级代谢产物途径的相互调控
J Ind Microbiol Biotechnol. 2017 May;44(4-5):525-535. doi: 10.1007/s10295-016-1830-y. Epub 2016 Aug 26.
3
Penicillium chrysogenum: Beyond the penicillin.产黄青霉：超越青霉素。
Adv Appl Microbiol. 2024;127:143-221. doi: 10.1016/bs.aambs.2024.02.006. Epub 2024 Apr 16.
4
Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement.青霉素产生菌产黄青霉的蛋白质组分析：工业菌株改良过程中蛋白质变化的表征。
Mol Cell Proteomics. 2010 Jun;9(6):1182-98. doi: 10.1074/mcp.M900327-MCP200. Epub 2010 Feb 12.
5
Proteomics shows new faces for the old penicillin producer Penicillium chrysogenum.蛋白质组学揭示了产青霉素的老菌种产黄青霉的新面貌。
J Biomed Biotechnol. 2012;2012:105109. doi: 10.1155/2012/105109. Epub 2012 Jan 19.
6
Biosynthetic concepts for the production of β-lactam antibiotics in Penicillium chrysogenum.青霉素毕赤酵母中β-内酰胺抗生素生物合成的概念。
Biotechnol J. 2012 Feb;7(2):225-36. doi: 10.1002/biot.201100065. Epub 2011 Nov 7.
7
The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum.调控因子 PcRFX1 控制青霉素生物合成的三个基因在产黄青霉中的表达。
Fungal Genet Biol. 2012 Nov;49(11):866-81. doi: 10.1016/j.fgb.2012.08.002. Epub 2012 Aug 29.
8
Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs.两种不相关的真菌β-内酰胺产生菌产黄顶头孢霉和产黄青霉的转录组分析：在传统菌株改良计划中，受Velvet调控的基因是主要靶点。
BMC Genomics. 2017 Mar 31;18(1):272. doi: 10.1186/s12864-017-3663-0.
9
Impact of Classical Strain Improvement of on Amino Acid Metabolism during β-Lactam Production.经典菌株改良对β-内酰胺生产中氨基酸代谢的影响。
Appl Environ Microbiol. 2020 Jan 21;86(3). doi: 10.1128/AEM.01561-19.
10
Characterization of an autoinducer of penicillin biosynthesis in Penicillium chrysogenum.青霉素生物合成诱导物的特性研究。
Appl Environ Microbiol. 2011 Aug 15;77(16):5688-96. doi: 10.1128/AEM.00059-11. Epub 2011 Jul 1.

引用本文的文献

1
The Biocontrol and Growth-Promoting Potential of spp. and spp. in Sustainable Agriculture.[具体物种名称]属和[具体物种名称]属在可持续农业中的生物防治及促生长潜力
Plants (Basel). 2025 Jun 30;14(13):2007. doi: 10.3390/plants14132007.
2
Antibiotic resistance and virulence profile of isolated from wild Sumatran Orangutans ().从野生苏门答腊猩猩中分离出的抗生素耐药性和毒力特征（）。 （注：原文括号部分内容缺失，翻译可能不太完整准确）
J Adv Vet Anim Res. 2024 Dec 29;11(4):1066-1075. doi: 10.5455/javar.2024.k858. eCollection 2024 Dec.
3
Comparative Genomic Analysis Reveals Key Changes in the Genome of That Occurred During Classical Strain Improvement for Production of Antibiotic Cephalosporin C.

本文引用的文献

1
Transport systems, intracellular traffic of intermediates and secretion of β-lactam antibiotics in fungi.真菌中的转运系统、中间体的细胞内运输及β-内酰胺抗生素的分泌
Fungal Biol Biotechnol. 2020 Apr 25;7:6. doi: 10.1186/s40694-020-00096-y. eCollection 2020.
2
Label-Free Proteomic Analysis of Molecular Effects of 2-Methoxy-1,4-naphthoquinone on .2-甲氧基-1,4-萘醌对 … 的分子作用的无标记蛋白质组学分析
Int J Mol Sci. 2019 Jul 14;20(14):3459. doi: 10.3390/ijms20143459.
3
Quantitative proteomic profiling of ochratoxin A repression in Penicillium nordicum by protective cultures.
比较基因组分析揭示了在用于生产抗生素头孢菌素C的经典菌株改良过程中，[具体菌株名称未给出]基因组发生的关键变化。
Int J Mol Sci. 2024 Dec 28;26(1):181. doi: 10.3390/ijms26010181.
4
CRISPR/Cas9-Mediated Disruption of the Gene and Its Impact on Growth, Development, and Penicillin Production in .CRISPR/Cas9介导的基因破坏及其对……生长、发育和青霉素生产的影响。
J Fungi (Basel). 2023 Oct 13;9(10):1010. doi: 10.3390/jof9101010.
5
Pr Affects the Production of Roquefortine C, Mycophenolic Acid, and Andrastin A in , but It Has Little Impact on Asexual Development.Pr影响罗克福汀C、霉酚酸和安曲汀A在……中的产生，但对无性发育影响很小。
J Fungi (Basel). 2023 Sep 22;9(10):954. doi: 10.3390/jof9100954.
6
Reconciliation and evolution of Penicillium rubens genome-scale metabolic networks-What about specialised metabolism?红青霉全基因组代谢网络的调和与进化——特殊代谢物如何？
PLoS One. 2023 Aug 30;18(8):e0289757. doi: 10.1371/journal.pone.0289757. eCollection 2023.
7
Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance.超越青霉素：丝状真菌在抗生素耐药时代用于药物发现的潜力
Antibiotics (Basel). 2023 Jul 29;12(8):1250. doi: 10.3390/antibiotics12081250.
8
Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle.真菌生物合成基因簇用于次生代谢产物的生产：主要类型、在菌株改良中的核心作用，以及根据钢琴原理进行的调控。
Int J Mol Sci. 2023 Jul 6;24(13):11184. doi: 10.3390/ijms241311184.
9
Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids.用于生产生物合成大麻素的生物技术真菌平台。
J Fungi (Basel). 2023 Feb 10;9(2):234. doi: 10.3390/jof9020234.
10
Interconnected Set of Enzymes Provide Lysine Biosynthetic Intermediates and Ornithine Derivatives as Key Precursors for the Biosynthesis of Bioactive Secondary Metabolites.相互关联的酶系提供赖氨酸生物合成中间体和鸟氨酸衍生物，作为生物活性次生代谢物生物合成的关键前体。
Antibiotics (Basel). 2023 Jan 12;12(1):159. doi: 10.3390/antibiotics12010159.
利用保护培养物对青霉中赭曲霉毒素 A 的抑制作用进行定量蛋白质组学分析。
Int J Food Microbiol. 2019 Sep 16;305:108243. doi: 10.1016/j.ijfoodmicro.2019.108243. Epub 2019 Jun 3.
4
A dynamic model-based preparation of uniformly-C-labeled internal standards facilitates quantitative metabolomics analysis of Penicillium chrysogenum.基于动态模型的均匀 13C 标记内标制备促进了青霉素菌的定量代谢组学分析。
J Biotechnol. 2019 Jun 20;299:21-31. doi: 10.1016/j.jbiotec.2019.04.021. Epub 2019 Apr 29.
5
Sensing and transduction of nutritional and chemical signals in filamentous fungi: Impact on cell development and secondary metabolites biosynthesis.丝状真菌中营养和化学信号的感应和转导：对细胞发育和次生代谢物生物合成的影响。
Biotechnol Adv. 2019 Nov 1;37(6):107392. doi: 10.1016/j.biotechadv.2019.04.014. Epub 2019 Apr 26.
6
Regulation of the phosphate metabolism in Streptomyces genus: impact on the secondary metabolites.链霉菌属磷酸盐代谢的调控：对次级代谢物的影响。
Appl Microbiol Biotechnol. 2019 Feb;103(4):1643-1658. doi: 10.1007/s00253-018-09600-2. Epub 2019 Jan 10.
7
Proteomics and Penicillium chrysogenum: Unveiling the secrets behind penicillin production.蛋白质组学与产黄青霉：青霉素生产背后的秘密。
J Proteomics. 2019 Apr 30;198:119-131. doi: 10.1016/j.jprot.2018.11.006. Epub 2018 Nov 7.
8
Functional Transcriptomics for Bacterial Gene Detectives.功能转录组学：细菌基因侦探的利器。
Microbiol Spectr. 2018 Sep;6(5). doi: 10.1128/microbiolspec.RWR-0033-2018.
9
Comprehensive Improvement of Sample Preparation Methodologies Facilitates Dynamic Metabolomics of Aspergillus niger.全面改进样品制备方法有助于黑曲霉的动态代谢组学研究。
Biotechnol J. 2019 Mar;14(3):e1800315. doi: 10.1002/biot.201800315. Epub 2018 Sep 20.
10
Catabolism of phenylacetic acid in Penicillium rubens. Proteome-wide analysis in response to the benzylpenicillin side chain precursor.红色红曲霉中苯乙酸的分解代谢。对苯青霉素侧链前体响应的蛋白质组全分析。
J Proteomics. 2018 Sep 15;187:243-259. doi: 10.1016/j.jprot.2018.08.006. Epub 2018 Aug 6.