Woman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona, Italy.
Medical Oncology Unit, Polytechnic University of Marche, Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I, GM Lancisi, G Salesi, Ancona, Italy.
In Vivo. 2020 Jul-Aug;34(4):2147-2152. doi: 10.21873/invivo.12021.
BACKGROUND/AIM: Clear cell carcinoma of the abdominal wall is a sporadic event. To date, about thirty cases have been reported in the literature. This article provides a case report and literature review of an infrequent occurrence with poor prognosis.
A 45-year-old woman with pelvic pain and an abdominal mass came to our attention. Her medical history was notable for two previous cesarean sections. Physical examination revealed a smooth, multilocular mass measuring about 20 cm, arising from the previous surgical scar. Histology revealed clear-cell carcinoma resulting from the transformation of abdominal wall endometriosis. Given the disease extent, the patient underwent front-line chemotherapy. After several and multiple chemotherapy regimens, there was a disease progression that resulted in the death of the patient in 7 months. The literature review showed that a previous cesarean section was present in 91% of cases. Besides, approximately 26.5% of women died within 12 months of being diagnosed. The mean age of women was 45.88 years, while the average size of the lesion was 11 cm.
Clear cell carcinoma is a rare but occurring event. Middle-aged women showing an abdominal wall mass in close relation with a surgical scar from a previous cesarean section must be promptly investigated. Treatment options usually include surgery and chemotherapy with poor results.
背景/目的：腹壁透明细胞癌是一种散发性事件。迄今为止，文献中约有三十例报道。本文提供了一例罕见且预后不良的病例报告和文献复习。
一名 45 岁女性因盆腔疼痛和腹部肿块就诊。她的病史中值得注意的是有两次剖宫产史。体格检查显示，从前次手术疤痕处出现了一个光滑的多房性肿块，大小约 20 厘米。组织学显示，腹壁子宫内膜异位症转化为透明细胞癌。由于疾病的范围，患者接受了一线化疗。在进行了几次和多种化疗方案后，疾病进展导致患者在 7 个月后死亡。文献复习显示，91%的病例有剖宫产史。此外，约 26.5%的女性在确诊后 12 个月内死亡。女性的平均年龄为 45.88 岁，病变的平均大小为 11 厘米。
透明细胞癌虽然罕见，但确实会发生。中年女性如果出现与先前剖宫产术相关的腹壁肿块，必须立即进行调查。治疗选择通常包括手术和化疗，但结果不佳。
