Bellalah Ahlem, Lahbecha Bahaeddine, Zokar Olfa, Ghannouchi Mossaab, Garrach Saber, Ben Khlifa Mohamed, Nacef Karim, Boudokhan Moez, Njim Leila, Zakhama Abdelfatteh
Department of Pathology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Department of Gynecology and Obstetrics, Monastir Maternity and Neonatology Center, Tunisia.
Ann Med Surg (Lond). 2022 Jun 18;79:104038. doi: 10.1016/j.amsu.2022.104038. eCollection 2022 Jul.
Clear cell carcinoma of abdominal wall is a very rare and aggressive disease. It is mostly related to malignant transformation of abdominal wall endometriosis. This paper provides a new case report and a literature review of primitive abdominal wall clear cell carcinoma.
A 45-year-old woman with a history of a two previous caesarian section presented to the outpatient department with a tumor mass evolving since 10 years in the lower right quadrant of her abdomen. Imaging studies revealed a voluminous subcutaneous mass developing at the expense of the anterior abdominal wall. Surgical resection of the mass was performed. Histopathological examination along with immunohistochemical analysis were consistent with clear cell carcinoma. Biopsies of the endometrium and ovaries were performed and were negative for malignancy. The patient underwent therefore a hysterectomy with bilateral salpingo-oophorectomy which did not reveal any disease. The diagnosis of primitive clear cell carcinoma of the abdominal wall was then confirmed.
Primitive clear cell carcinoma of the abdominal wall is an extremely rare form of cancer with usually poor prognosis. Clinicians must be aware of the possibility of malignancy of any swelling mass occurring near or within a caesarean section scar.
Reporting more such cases is still needed to further progress in the understanding of this malignancy in addition to the development of treatment strategies.
腹壁透明细胞癌是一种极为罕见且侵袭性强的疾病。它大多与腹壁子宫内膜异位症的恶变有关。本文提供了一例原发性腹壁透明细胞癌的新病例报告及文献综述。
一名45岁女性，有两次剖宫产史，因右下腹部一个已存在10年的肿瘤块前往门诊就诊。影像学检查显示一个巨大的皮下肿块，累及前腹壁。对该肿块进行了手术切除。组织病理学检查及免疫组化分析结果均符合透明细胞癌。对子宫内膜和卵巢进行了活检，结果显示无恶性病变。因此，患者接受了子宫切除术及双侧输卵管卵巢切除术，未发现任何疾病。随后确诊为原发性腹壁透明细胞癌。
原发性腹壁透明细胞癌是一种极为罕见的癌症形式，预后通常较差。临床医生必须意识到剖宫产瘢痕附近或内部出现的任何肿胀肿块存在恶变的可能性。
除了制定治疗策略外，仍需要报告更多此类病例，以便在对这种恶性肿瘤的认识上取得进一步进展。
