Jagtap Nitin, Kalapala Rakesh, Reddy D Nageshwar
Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.
J Neurogastroenterol Motil. 2020 Jul 30;26(3):391-396. doi: 10.5056/jnm19200.
BACKGROUND/AIMS: The functional luminal imaging probe (FLIP) can measure tissue distensibility and geometric changes through volumetric distention. The esophagogastric junction has been well studied using EndoFLIP, studies on pylorus are lacking. We aim to study biomechanical properties of pylorus using EndoFLIP to create normative data.
We performed a prospective study of 20 healthy volunteers (ages, 18-54 years; 10 men) who underwent pylorus evaluation using 12- cm FLIP placed across the pyloric sphincter. FLIP data were analyzed using FLIP planimetry plots at baseline and after administration of hyoscine butyl bromide injection.
The median pylorus distensibility index (P-DI) was 8.37 mm/mmHg (interquartile range, 4.22-13.04 mm/mmHg) at 40 mL balloon volume. The 90th percentile at 40 mL balloon for P-DI was 14.89 mm/mmHg, for cross-sectional area was 244.20 mm/mmHg, and diameter and pressure were 17.58 mm and 48.84 mmHg, respectively. There was significant increase in P-DI after administration of hyoscine butyl bromide injection ( < 0.05).
The normative values can be used as reference values for pyloric distensibility. This reference can be used in studies of related to pyloric diseases such as gastroparesis.
背景/目的：功能性腔内成像探头（FLIP）可通过容积扩张测量组织扩张性和几何变化。使用EndoFLIP对食管胃交界进行了充分研究，但缺乏对幽门的研究。我们旨在使用EndoFLIP研究幽门的生物力学特性以创建标准数据。
我们对20名健康志愿者（年龄18 - 54岁；10名男性）进行了一项前瞻性研究，这些志愿者使用横跨幽门括约肌放置的12厘米FLIP进行幽门评估。在基线和注射丁溴东莨菪碱后，使用FLIP平面测量图分析FLIP数据。
在球囊容积为40 mL时，幽门扩张性指数（P - DI）中位数为8.37 mm/mmHg（四分位间距，4.22 - 13.04 mm/mmHg）。在球囊容积为40 mL时，P - DI的第90百分位数为14.89 mm/mmHg，横截面积为244.20 mm²，直径和压力分别为17.58 mm和48.84 mmHg。注射丁溴东莨菪碱后P - DI有显著增加（P < 0.05）。
这些标准值可作为幽门扩张性的参考值。该参考可用于与诸如胃轻瘫等幽门疾病相关的研究。
