Seyedrezazadeh Ensiyeh, Moghaddam Masoud Pour, Ansarin Khalil, Asghari Jafarabadi Mohammad, Sharifi Akbar, Sharma Sangita, Kolahdooz Fariba
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mt Kuring-Gai Medical Centre, Suite 5,6, 757 Pacific Hwy, Mount Kuring-Gai NSW 2080.
Tanaffos. 2019 Apr;18(4):294-309.
The relationship between dietary pattern and the risk of chronic obstructive pulmonary disease (COPD) has been described; however, the exclusive role of dietary factors remains controversial. Hence, we conducted this systematic meta-analysis to clarify the role of some nutrients and antioxidant vitamins in the risk of COPD.
PubMed, Embase, and Scopus databases were searched for studies evaluating the associations between COPD outcome measures, symptoms, and mortality, and intake of fruits and vegetables, fiber, fish, n-3 or n-6 fatty acids, and antioxidant vitamins in adults. The random-effect model meta-analyses were used to pool the results.
Ten cohort, six case-control, and 20 cross-sectional studies were identified. The pooled relative risks (RRs) of the COPD and confidence intervals (CIs) for the highest intake group compared with the lowest intake group were 0.74 (95% CI: 0.65-0.85) for fruit, 0.65 (95% CI: 0.55-0.78) for dietary fiber, 0.71 (95% CI: 0.58-0.85) for fish, and 0.89 (95% CI: 0.76-0.99) for vitamin C. No association was observed between the risk of COPD and the intake of vegetables, n-3 fatty acids, vitamin E, and β-carotene; however, it was associated with n-6 fatty acids 1.06 (95% CI: 0.87-1.30).
The results suggested that a higher intake of fruits, probably dietary fiber, and fish reduce the risk of COPD.
饮食模式与慢性阻塞性肺疾病（COPD）风险之间的关系已有描述；然而，饮食因素的独立作用仍存在争议。因此，我们进行了这项系统的荟萃分析，以阐明某些营养素和抗氧化维生素在COPD风险中的作用。
检索了PubMed、Embase和Scopus数据库，以查找评估成人COPD结局指标、症状和死亡率与水果和蔬菜、纤维、鱼类、n-3或n-6脂肪酸以及抗氧化维生素摄入量之间关联的研究。采用随机效应模型荟萃分析汇总结果。
共纳入10项队列研究、6项病例对照研究和20项横断面研究。与最低摄入量组相比，最高摄入量组COPD的合并相对风险（RR）及置信区间（CI）分别为：水果0.74（95%CI：0.65-0.85）、膳食纤维0.65（95%CI：0.55-0.78）、鱼类0.71（95%CI：0.58-0.85）、维生素C 0.89（95%CI：0.76-0.99）。未观察到COPD风险与蔬菜、n-3脂肪酸、维生素E和β-胡萝卜素摄入量之间存在关联；然而，其与n-6脂肪酸有关联，RR为1.06（95%CI：0.87-1.30）。
结果表明，较高的水果摄入量，可能还有膳食纤维和鱼类摄入量，可降低COPD风险。
