血清维生素 A 和 E 浓度与肺功能参数及慢性阻塞性肺疾病的相关性研究。
Associations of Serum Vitamin A and E Concentrations with Pulmonary Function Parameters and Chronic Obstructive Pulmonary Disease.
机构信息
Department of Foods and Nutrition, College of Science and Technology, Kookmin University, Seoul 02707, Republic of Korea.
出版信息
Nutrients. 2024 Sep 21;16(18):3197. doi: 10.3390/nu16183197.
BACKGROUND/OBJECTIVES: Oxidative stress, an imbalance between oxidants and antioxidants, is known to affect pulmonary function (PF), thereby leading to the development of chronic obstructive pulmonary disease (COPD). However, data on the associations of serum vitamin A and E concentrations with PF parameters and COPD are inconsistent. The present cross-sectional study aimed to investigate these associations, considering inflammatory status.
PARTICIPANTS/METHODS: This study included 2005 male and female adults aged ≥40 years who had participated in a population-based national survey. Spirometry without a bronchodilator was conducted to yield PF parameters, such as forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio, which were used to define COPD. Serum vitamin A (retinol) and E (α-tocopherol) concentrations were assayed. Multivariable regression analysis was performed after adjusting for potential confounding variables.
RESULTS
Serum vitamin A concentration was positively associated with FEV1 ( for trend < 0.01) among all participants. In addition, the odds ratio (95% confidence interval) of the highest serum vitamin A concentration tertile for the prevalence of COPD, which was defined by the FEV1/FVC ratio < 0.7, was 0.53 (0.31, 0.90) compared with that of the lowest tertile ( for trend < 0.05). Analysis stratified by a cutoff point of 1 mg/L serum high-sensitivity C-reactive protein (hs-CRP) revealed that such associations with FEV1 and COPD prevalence were stronger in participants with lower hs-CRP levels ( for trend < 0.05). In contrast, serum vitamin E concentration was associated with neither PF parameters nor COPD prevalence.
CONCLUSIONS
These findings suggest that serum vitamin A concentration may be important in preventing the progressive decline in PF parameters that results in COPD. Further epidemiological investigations are warranted to evaluate the causal associations of antioxidant vitamin status with PF parameters and COPD.
背景/目的：氧化应激是一种氧化剂和抗氧化剂之间失衡的状态，已知其会影响肺功能（PF），从而导致慢性阻塞性肺疾病（COPD）的发生。然而，关于血清维生素 A 和 E 浓度与 PF 参数和 COPD 之间关系的数据并不一致。本横断面研究旨在调查这些关联，并考虑炎症状态。
参与者/方法：本研究纳入了 2005 名年龄≥40 岁的男性和女性成年人，他们参加了一项基于人群的全国性调查。进行无支气管扩张剂的肺活量测定以获得 PF 参数，如一秒用力呼气量（FEV1）、用力肺活量（FVC）和 FEV1/FVC 比值，这些参数用于定义 COPD。检测血清维生素 A（视黄醇）和 E（α-生育酚）浓度。在调整潜在混杂变量后，进行多变量回归分析。
结果
在所有参与者中，血清维生素 A 浓度与 FEV1 呈正相关（趋势<0.01）。此外，与最低三分位组相比，血清维生素 A 浓度最高三分位组 COPD 患病率（定义为 FEV1/FVC 比值<0.7）的比值比（95%置信区间）为 0.53（0.31，0.90）（趋势<0.05）。根据 1 毫克/升血清高敏 C 反应蛋白（hs-CRP）的截断值进行分层分析显示，在 hs-CRP 水平较低的参与者中，与 FEV1 和 COPD 患病率的相关性更强（趋势<0.05）。相比之下，血清维生素 E 浓度与 PF 参数和 COPD 患病率均无关。
结论
这些发现表明，血清维生素 A 浓度可能在预防导致 COPD 的 PF 参数进行性下降方面很重要。需要进一步进行流行病学研究，以评估抗氧化维生素状态与 PF 参数和 COPD 之间的因果关系。
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