School of Social Development and Public Policy, Beijing Normal University, 19 Xinjiekouwai Street, Beijing, 100875, China.
Department of Environmental and Occupational Health, School of Public Health, Indiana University Bloomington, 1025 E 7th street, Bloomington, IN, 47405, USA.
Breast Cancer Res Treat. 2020 Aug;183(1):217-226. doi: 10.1007/s10549-020-05764-6. Epub 2020 Jun 30.
It has been hypothesized that selenium (Se) can prevent cancer, and that Se deficiency may be associated with an increased risk of breast cancer. However, findings from epidemiological studies have been inconsistent. The objective of this study was to assess the association between Se intake and risk of breast cancer in the Women's Health Initiative (WHI).
This study included 145,033 postmenopausal women 50-79 years who completed baseline questionnaires between October 1993 and December 1998, which addressed dietary and supplemental Se intake and breast cancer risk factors. The association between baseline Se intake and incident breast cancer was examined in Cox proportional hazards analysis.
During a mean follow-up of 15.5 years, 9487 cases of invasive breast cancer were identified. Total Se (highest versus lowest quartile: HR 1.00, 95% CI 0.92-1.09, P = 0.66), dietary Se (highest versus lowest quartile: HR 0.99, 95% CI 0.89-1.08, P = 0.61), and supplemental Se (yes versus no: HR 0.99, 95% CI 0.95-1.03) were not associated with breast cancer incidence.
This study indicates that Se intake is not associated with incident breast cancer among postmenopausal women in the United States. Further studies are needed to confirm our findings by using biomarkers such as toenail Se to reduce the potential for misclassification of Se status.
有假说认为，硒（Se）可以预防癌症，且硒缺乏可能与乳腺癌风险增加有关。然而，流行病学研究的结果并不一致。本研究旨在评估女性健康倡议（WHI）中硒摄入与乳腺癌风险之间的关系。
本研究纳入了 145033 名绝经后女性，年龄在 50-79 岁之间，她们于 1993 年 10 月至 1998 年 12 月期间完成了基线问卷调查，问卷内容涉及膳食和补充硒摄入以及乳腺癌风险因素。采用 Cox 比例风险分析评估基线硒摄入与乳腺癌发病风险之间的关系。
在平均 15.5 年的随访期间，共发现 9487 例浸润性乳腺癌病例。总硒（最高四分位与最低四分位相比：HR 1.00，95%CI 0.92-1.09，P=0.66）、膳食硒（最高四分位与最低四分位相比：HR 0.99，95%CI 0.89-1.08，P=0.61）和补充硒（是与否相比：HR 0.99，95%CI 0.95-1.03）与乳腺癌发病率均无相关性。
本研究表明，在美国绝经后妇女中，硒摄入与乳腺癌发病无关。需要进一步的研究，通过使用生物标志物（如趾甲硒）来确认我们的发现，以减少硒状态的潜在分类错误。
