Department of Occupational Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, P.O. Box. 14115-331, Iran.
Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, P.O. Box. 6153- 14155, Velenjak St., Shahid Chamran Highway, Tehran, Iran.
Environ Monit Assess. 2020 Jun 30;192(7):472. doi: 10.1007/s10661-020-08422-y.
Many workers are exposed to health problems arising from molds, fungi, and their toxins during waste processing. Aflatoxin B (AFB) level in airborne and settled dust, aflatoxin B-albumin (AFB-Alb) adduct in serum, liver and kidney biochemical tests, and body redox change of workers in municipal dry waste-processing sites were investigated. The surface, personal, and area air dust and the blood of workers' samples were collected from the plastic and bread waste-sorting sections in three recycling municipal dry waste sites. Digestion (only for serum samples), passed through SPE cartridge, elution, and collection with methanol, immune-affinity column clean-up, and HPLC system equipped with post-column derivatization method and fluorescence detection were performed for determination of AFB and AFB-Alb levels in the samples. The mean level of dust and AFB in the personal and area air, and in the settled dust and the AFB-Alb in the serum of workers in the bread waste sorting, was higher than plastic waste-sorting samples, in all of the sites. The differences in the biochemical profiles of subjects exposed to aflatoxin B as compared to the control group especially in liver and kidney function parameters as well as antioxidant factors of the serum were significant. The workers in handling of municipal waste may be exposed to potentially hazardous levels of aflatoxin B. The adverse effects of AFB on the kidney and liver may be caused by changes in the redox system.
许多工人在处理废物时会接触到由霉菌、真菌及其毒素引起的健康问题。研究了空气中悬浮尘埃和沉降尘埃中的黄曲霉毒素 B（AFB）水平、血清中黄曲霉毒素 B-白蛋白（AFB-Alb）加合物、肝肾功能生化检查以及工人在城市干废物处理场所的体内氧化还原变化。从三个回收城市干废物处理场所的塑料和面包废物分拣区采集了工人表面、个人和区域空气尘埃和血液样本。对血清样品进行消化（仅用于血清样品）、通过 SPE 小柱、洗脱和用甲醇收集、免疫亲和柱净化以及配备柱后衍生化方法和荧光检测的 HPLC 系统进行了 AFB 和 AFB-Alb 水平的测定。在所有场所，面包废物分拣区工人的个人和区域空气尘埃以及沉降尘埃中的尘埃和 AFB-Alb 水平以及血清中的 AFB-Alb 水平均高于塑料废物分拣区的工人。与对照组相比，暴露于黄曲霉毒素 B 的研究对象的生化特征差异显著，尤其是在肝功能和肾功能参数以及血清抗氧化因子方面。处理城市废物的工人可能会接触到潜在危险水平的黄曲霉毒素 B。AFB 对肾脏和肝脏的不利影响可能是由氧化还原系统的变化引起的。
