Department of Occupational Health, Faculty of Health, Ilam University of Medical Sciences, Ilam 693917714, Iran.
Department of Occupational Health, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box. 14115-331, Tehran, Iran.
Ecotoxicol Environ Saf. 2022 Dec 15;248:114305. doi: 10.1016/j.ecoenv.2022.114305. Epub 2022 Nov 18.
Exposure to dust, containing different fungi metabolites such as aflatoxins is a risk factor for developing liver and kidney health abnormalities. Occupational evaluation of the aflatoxin's exposure-induced health abnormalities should include the monitoring of bioaerosols in the workplace and personal air, and applying of appropriate blood biomarkers to assess Aflatoxin B (AFB) detrimental effects on a worker's health. However, to the best of our knowledge, these appropriate methods, especially determining the associated-adverse effects on health, following exposure, haven't been well documented in the literature at the wet waste handling sites. In the current study, the AFB quantity in the area, personal, and settled dust in wet household waste handling samples and AFB-Albumin levels in the serum of workers in comparison with the control group were determined using high-pressure liquid chromatography with a fluorescent detector (HPLC-FLD) methods. Moreover, the adverse effects of AFB on the liver and kidney biochemical profiles of the exposed workers and its relation to antioxidant capacity in the household wet waste sorting were recorded in a consolidated investigation. The results demonstrated that the average airborne dust concentration and its associated AFB content were significantly higher in wet waste management sections as compared to the control place, corresponding to the serum AFB-Albumin levels of workers. Furthermore, AFB-induced changes in the serum biochemicals evaluating liver and kidney function tests and antioxidant profiles of workers in wet waste handling sections were indicative of their function abnormalities. The results imply AFB-induced adverse effects on the liver and kidney functions may be mediated through the body redox system modulation.
暴露于含有不同真菌代谢物（如黄曲霉毒素）的灰尘中是导致肝肾功能异常的危险因素。职业性评估黄曲霉毒素暴露引起的健康异常应包括监测工作场所和个人空气中的生物气溶胶，并应用适当的血液生物标志物来评估黄曲霉毒素 B（AFB）对工人健康的有害影响。然而，据我们所知，这些适当的方法，特别是确定在湿废物处理场所接触后的相关不良健康影响，尚未在文献中得到很好的记录。在本研究中，使用高压液相色谱荧光检测器（HPLC-FLD）方法，确定了该地区、个人和湿家庭废物处理样本中沉降灰尘中的 AFB 量，以及工人血清中的 AFB-白蛋白水平，并与对照组进行了比较。此外，还在综合调查中记录了 AFB 对暴露工人的肝肾功能生化谱的不良影响及其与家庭湿废物分类中的抗氧化能力的关系。结果表明，与对照地点相比，在湿废物管理区空气中的尘埃浓度及其相关的 AFB 含量明显更高，这与工人血清中 AFB-白蛋白水平相对应。此外，AFB 诱导的血清生化变化，用于评估肝脏和肾脏功能试验以及湿废物处理区工人的抗氧化谱，表明其功能异常。结果表明，AFB 对肝肾功能的不良影响可能是通过体内氧化还原系统的调节介导的。
