Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?
作者信息
Abobaker Anis
机构信息
Spire Fylde Coast Hospital, St Walburgas road, Blackpool, FY3 8BP, UK.
出版信息
Eur J Clin Pharmacol. 2020 Nov;76(11):1619-1620. doi: 10.1007/s00228-020-02942-9. Epub 2020 Jun 30.
Abstract
摘要
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Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?铁螯合作为新型冠状病毒肺炎的辅助治疗能否改善临床结局？
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Critical role for iron accumulation in the pathogenesis of fibrotic lung disease.铁蓄积在纤维性肺病发病机制中的关键作用。
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.中国武汉 99 例 2019 年新型冠状病毒肺炎患者的流行病学和临床特征：描述性研究。
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Deferoxamine compensates for decreases in B cell counts and reduces mortality in enterovirus 71-infected mice.去铁胺可弥补B细胞数量的减少，并降低肠道病毒71型感染小鼠的死亡率。
Mar Drugs. 2014 Jul 7;12(7):4086-95. doi: 10.3390/md12074086.
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Viral infection and iron metabolism.病毒感染与铁代谢
Nat Rev Microbiol. 2008 Jul;6(7):541-52. doi: 10.1038/nrmicro1930.
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The iron cycle and oxidative stress in the lung.肺中的铁循环与氧化应激
Free Radic Biol Med. 2004 Apr 1;36(7):850-7. doi: 10.1016/j.freeradbiomed.2003.12.008.
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Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A.铁螯合和羟基自由基清除可降低肺炎衣原体或甲型流感病毒感染后内皮细胞的炎症反应。
Eur J Clin Invest. 2002 Mar;32 Suppl 1:84-90. doi: 10.1046/j.1365-2362.2002.0320s1084.x.
8
Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin.去铁胺、去铁酮和博来霉素等铁螯合剂对人单核血细胞中1型人类免疫缺陷病毒复制的抑制作用。
J Infect Dis. 2000 Feb;181(2):484-90. doi: 10.1086/315223.
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