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减重与代谢手术的结果:一项更新的 5 年回顾。

Outcomes in Bariatric and Metabolic Surgery: an Updated 5-Year Review.

机构信息

Department of General Surgery, Banner University Medical Center - Phoenix, University of Arizona, 1441 N 12th Street, 1st floor, Phoenix, AZ, 85006, USA.

Ira A. Fulton Chair in Bariatric Surgery and Metabolic Disorders, Institute for Obesity and Metabolic Disorders, Banner University Medical Center - Phoenix, University of Arizona, 1441 N 12th Street, 1st floor, Phoenix, AZ, 85006, USA.

出版信息

Curr Obes Rep. 2020 Sep;9(3):380-389. doi: 10.1007/s13679-020-00389-8.

Abstract

PURPOSE OF REVIEW

Knowledge regarding postoperative outcomes after bariatric and metabolic surgery continues to evolve. This review highlights key findings in outcomes research over the last 5 years related to weight loss, remission of obesity-related disease, reflux, revisional surgery, robotic-assisted surgical platforms, and adolescent populations.

RECENT FINDINGS

Sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) produce similar weight loss patterns at 5 years, while duodenal switch (BPD/DS) and related procedures are associated with maximal weight loss overall and optimal resolution of obesity-related comorbidities. Remission of type 2 diabetes mellitus (T2DM) following surgery is more likely in patients who are not insulin dependent prior to surgery. Bariatric and metabolic surgery offers a significant protective effect against coronary artery disease (CAD) and associated interventions in both diabetic and nondiabetic patients, as well as heart failure (HF). Gastroesophageal reflux disease (GERD) and dysphagia following SG are common, and routine endoscopic surveillance for Barrett's esophagus may be of significant utility. Robotic-assisted laparoscopic platforms concur similar outcomes to laparoscopic intervention, with a potential benefit in high BMI patients. Revisional surgery is most commonly performed for weight regain and/or inadequate weight loss following an index procedure, or reflux, and generally characterized by higher postoperative complication rates and longer inpatient lengths of stay (LOS). Surgical intervention in adolescent populations has similar weight loss and postoperative complication profiles to those seen in adult populations, with improved outcomes related to T2DM. Bariatric and metabolic surgery continues to evolve as a treatment for obesity and obesity-related comorbidities. While effective for weight loss and remission of obesity-related disease, SG is associated with high rates of postoperative GERD.

摘要

目的综述

减重和代谢手术的术后结果的相关知识仍在不断发展。本综述重点介绍了过去 5 年与减重、肥胖相关疾病缓解、反流、翻修手术、机器人辅助手术平台和青少年人群相关的研究结果。

最新发现

袖状胃切除术(SG)和胃旁路术(RYGB)在术后 5 年的减重效果相似,而十二指肠转位术(BPD/DS)和相关手术总体上与最大减重和肥胖相关合并症的最佳缓解相关。术前依赖胰岛素的患者手术后发生 2 型糖尿病(T2DM)缓解的可能性更大。减重和代谢手术为糖尿病和非糖尿病患者提供了对冠心病(CAD)和相关干预的显著保护作用,以及心力衰竭(HF)。SG 后的胃食管反流病(GERD)和吞咽困难很常见,常规进行 Barrett 食管的内镜监测可能具有重要意义。机器人辅助腹腔镜平台与腹腔镜干预具有相似的结果,对于高 BMI 患者可能具有潜在的益处。翻修手术最常用于指数手术后体重反弹和/或减重不足,或反流,通常具有更高的术后并发症发生率和更长的住院时间(LOS)。青少年人群的手术干预与成人人群相似,具有相似的减重和术后并发症情况,T2DM 的改善与手术相关。减重和代谢手术作为肥胖和肥胖相关合并症的治疗方法仍在不断发展。虽然 SG 对减重和肥胖相关疾病缓解有效,但与术后 GERD 发生率高有关。

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