Lu Yuanyuan, Luo Jianguang, Huang Xuefeng, Kong Lingyi
Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Jiangsu, Nanjing 210009, PR China.
Steroids. 2009 Jan;74(1):95-101. doi: 10.1016/j.steroids.2008.09.011. Epub 2008 Oct 2.
Two novel C-22 steroidal lactone saponins, namely solanolactosides A, B (1, 2) and two new spirostanol glycosides, namely torvosides M, N (3, 4) were isolated from ethanol extract of aerial parts of Solanum torvum. Their structures were characterized as solanolide 6-O-[alpha-l-rhamnopyranosyl-(1-->3)-O-beta-d-quinovopyranoside] (1), solanolide 6-O-[beta-d-xylopyranosyl-(1-->3)-O-beta-d-quinovopyranoside] (2), yamogenin 3-O-[beta-d-glucopyranosyl-(1-->6)-O-beta-d-glucopyranoside] (3) and neochlorogenin 3-O-[beta-d-glucopyranosyl-(1-->6)-O-beta-d-glucopyranoside] (4) on the basis of spectroscopic analysis. The cytotoxicities of the saponins (1-4) were evaluated in vitro against a panel of human cancer cell lines. Compounds 3 and 4 showed significant cytotoxic activity with the cell lines.
从刺茄地上部分的乙醇提取物中分离得到两种新型C-22甾体内酯皂苷，即茄甾内酯苷A、B（1, 2）以及两种新的螺旋甾烷醇糖苷，即刺茄皂苷M、N（3, 4）。通过光谱分析，它们的结构被鉴定为茄内酯6-O-[α-L-鼠李吡喃糖基-(1→3)-O-β-D-奎诺吡喃糖苷]（1）、茄内酯6-O-[β-D-木吡喃糖基-(1→3)-O-β-D-奎诺吡喃糖苷]（2）、薯蓣皂苷元3-O-[β-D-吡喃葡萄糖基-(1→6)-O-β-D-吡喃葡萄糖苷]（3）和新绿原酸3-O-[β-D-吡喃葡萄糖基-(1→6)-O-β-D-吡喃葡萄糖苷]（4）。对皂苷（1 - 4）针对一组人类癌细胞系进行了体外细胞毒性评估。化合物3和4对这些细胞系显示出显著的细胞毒性活性。
