Li Jinsheng, Zhang Lu, Huang Cheng, Guo Fujiang, Li Yiming
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, PR China.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, PR China.
Fitoterapia. 2014 Mar;93:209-15. doi: 10.1016/j.fitote.2014.01.009. Epub 2014 Jan 18.
The fruits of Solanum torvum Swartz, commonly known as Turkey berry, are edible and commonly used as a vegetable in the South Indian population's diet and as an essential ingredient in Thai cuisine. Five new steroidal glycosides together with five known ones were isolated from the fruits of S. torvum Swartz. Based on chemical and spectral evidence, the five new compounds were identified to be 25(S)-26-O-β-D-glucopyranosyl-5α-furost-22(20)-en-3β,6α,26-triol-6-O-[α-L-rhamnopyranosyl-(1→3)-O-β-D-quinovopyranoside] (1), 25(S)-26-O-β-D-glucopyranosyl-5α-furost-22(20)-en-3-one-6α,26-diol-6-O-[α-L-rhamnopyranosyl-(1→3)-O-β-D-quinovopyranoside] (2), 25(S)-26-O-β-D-glucopyranosyl-5α-furost-22(20)-en-3β,6α,26-triol-6-O-β-D-quinovopyranoside (3), 5α-pregn-16-en-20-one-3β,6α-diol-6-O-[α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranoside] (4), and 5α-pregn-16-en-3,20-dione-6α-ol-6-O-[α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranoside] (5). These new compounds were assayed for cytotoxicities in vitro, and 1 to 4 showed cyotoxic activity against the human melanoma cell line A375, with IC50 values of 30 μM to 260 μM.
刺天茄（Solanum torvum Swartz）的果实，通常被称为土耳其浆果，是可食用的，在南印度人群的饮食中常被用作蔬菜，也是泰国菜肴的重要成分。从刺天茄的果实中分离出了五种新的甾体糖苷以及五种已知的甾体糖苷。基于化学和光谱证据，确定这五种新化合物分别为25(S)-26-O-β-D-吡喃葡萄糖基-5α-呋甾-22(20)-烯-3β,6α,26-三醇-6-O-[α-L-鼠李吡喃糖基-(1→3)-O-β-D-奎诺吡喃糖苷]（1）、25(S)-26-O-β-D-吡喃葡萄糖基-5α-呋甾-22(20)-烯-3-酮-6α,26-二醇-6-O-[α-L-鼠李吡喃糖基-(1→3)-O-β-D-奎诺吡喃糖苷]（2）、25(S)-26-O-β-D-吡喃葡萄糖基-5α-呋甾-22(20)-烯-3β,6α,26-三醇-6-O-β-D-奎诺吡喃糖苷（3）、5α-孕甾-16-烯-20-酮-3β,6α-二醇-6-O-[α-L-鼠李吡喃糖基-(1→3)-β-D-奎诺吡喃糖苷]（4）和5α-孕甾-16-烯-3,20-二酮-6α-醇-6-O-[α-L-鼠李吡喃糖基-(1→3)-β-D-奎诺吡喃糖苷]（5）。对这些新化合物进行了体外细胞毒性测定，化合物1至4对人黑色素瘤细胞系A375显示出细胞毒性活性，IC50值为30μM至260μM。
