Faculty of Medicine, Pathology and Dermatology, Andology and STDs Departments.
Faculty of Medicine, Menoufia University , Shebein Elkom, Egypt.
J Immunoassay Immunochem. 2020 Sep 2;41(5):852-863. doi: 10.1080/15321819.2020.1785493. Epub 2020 Jul 1.
Psoriasis is a common chronic skin inflammatory disease characterized by an exaggerated proliferation of keratinocytes. B-cell receptor-associated protein 31 (BCAP 31) plays critical roles in induction of proliferation and apoptosis. The current study aimed at evaluation of the immunohistochemical localization of BCAP 31 in psoriatic skin compared to normal skin in addition of correlating BCAP31 expression with the clinical and pathological parameters of psoriasis. The present study was carried out on skin biopsies from 30 psoriatic patients and 10 normal skin (control group). BCAP31 was not expressed in normal skin either epidermis or dermis, while it was expressed in epidermis of 15 psoriatic cases and in dermis of 13 cases with a significant difference between the two groups ( < .05). Strong epidermal BCAP 31 expression was associated with marked parakeratosis ( = .025). There was a significant co-parallel epidermal and dermal expression of BCAP31 in psoriasis ( < .05). The role of BCAP 31 is not only confined to its expression by affected keratinocytes but extended to its localization to dermal lymphocytes where they were correlated with each other. The up- regulation of BCAP 31 in psoriatic lesion compared to normal skin may suggest its use as a target therapy for treatment of psoriasis that necessitates further studies to clarify.
银屑病是一种常见的慢性皮肤炎症性疾病，其特征为角质形成细胞的过度增殖。B 细胞受体相关蛋白 31（BCAP31）在诱导增殖和凋亡中发挥关键作用。本研究旨在评估 BCAP31 在银屑病皮肤中的免疫组织化学定位，并与银屑病的临床和病理参数相关联。本研究对 30 例银屑病患者和 10 例正常皮肤（对照组）的皮肤活检进行了研究。BCAP31 在正常皮肤的表皮或真皮中均不表达，而在 15 例银屑病病例的表皮和 13 例病例的真皮中表达，两组之间存在显著差异（ <.05）。强表皮 BCAP 31 表达与明显的角化不良相关（ =.025）。在银屑病中，BCAP31 的表皮和真皮表达呈显著的平行关系（ <.05）。BCAP 31 的作用不仅局限于受影响的角质形成细胞的表达，还扩展到其定位到真皮淋巴细胞，在那里它们彼此相关。与正常皮肤相比，银屑病病变中 BCAP 31 的上调可能表明其可作为治疗银屑病的靶向治疗，需要进一步研究以阐明。
