Abdou Asmaa Gaber, Hammam Mostafa, Saad Eman, Hassan Reem Ahmed Abdelaziz
Pathology Department, Faculty of Medicine, Menoufia University, Shebeen Elkom, Egypt.
Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Shebeen Elkom, Egypt.
J Cosmet Dermatol. 2022 Jan;21(1):380-386. doi: 10.1111/jocd.14086. Epub 2021 Mar 28.
Psoriasis is a chronic inflammatory skin disease with immune-mediated mechanism. Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelium of blood vessels.
The present study aims to evaluate immunohistochemical localization of endocan in psoriatic skin in comparison with normal skin and to correlate its expression with the clinical and pathological data of psoriasis.
PATIENTS/METHODS: Skin biopsies from 36 psoriatic patients and 40 normal subjects were taken and processed for immunohistochemical staining of endocan.
Endocan was expressed in 63.9% and in 36.1% of epidermal keratinocytes and dermal endothelial and inflammatory cells of psoriatic skin, respectively, compared with its expression in 30% of epidermis of normal skin. Diffuse epidermal expression of endocan was in favor of cases with more angiogenesis and its intense expression was in favor of marked acanthosis and with cases affecting trunk as main presentation. Positive dermal endocan expression was significantly associated with marked parakeratosis and with more angiogenesis.
Endocan is over-expressed in psoriatic skin from epidermal keratinocytes and dermal endothelial and inflammatory cells. Endocan enhances angiogenesis and proliferation of psoriatic skin contributing to pathogenic mechanisms of psoriasis.
银屑病是一种具有免疫介导机制的慢性炎症性皮肤病。内坎是一种由血管内皮表达的可溶性硫酸皮肤素蛋白聚糖。
本研究旨在评估内坎在银屑病皮肤与正常皮肤中的免疫组化定位，并将其表达与银屑病的临床和病理数据相关联。
患者/方法：取36例银屑病患者和40例正常受试者的皮肤活检组织，进行内坎的免疫组化染色。
内坎分别在63.9%的银屑病皮肤表皮角质形成细胞以及36.1%的真皮内皮细胞和炎性细胞中表达，而在正常皮肤30%的表皮中有表达。内坎在表皮的弥漫性表达有利于血管生成较多的病例，其强烈表达有利于显著的棘层肥厚以及以躯干为主要表现的病例。真皮内坎阳性表达与显著的角化不全以及较多的血管生成显著相关。
内坎在银屑病皮肤的表皮角质形成细胞、真皮内皮细胞和炎性细胞中过度表达。内坎促进银屑病皮肤的血管生成和增殖，有助于银屑病的发病机制。
