Abdou Asmaa Gaber, Farag Azza Gaber Antar, Abdelaziz Reem Ahmed, Samaka Rehab Mounir, Nabil Eman, Ali Marwa
Pathology Department, Faculty of Medicine, Menoufia University , Shebein El-Kom , Egypt.
Dermatology Department, Faculty of Medicine, Menoufia University , Shebein El-Kom , Egypt.
J Immunoassay Immunochem. 2019;40(5):515-527. doi: 10.1080/15321819.2019.1646660. Epub 2019 Jul 26.
Psoriasis is a chronic skin inflammatory disease with immunological, hyperproliferative and angiogenic dysfunction. MUC1 is a molecular sensor and signal transductor that responds to external stimuli generating cellular responses, which include cell proliferation, growth, differentiation, migration, invasion, survival and secretion of growth factors, and cytokines. The current study aimed at evaluation of the possible role of MUC1 in the pathogenesis of psoriasis through its immunohistochemical localization in involved and uninvolved psoriatic skin compared to normal skin in addition of correlating MUC1 expression with the clinical and pathological parameters of psoriasis. The current study investigated 30 patients with psoriasis and 10 controls. MUC1 was expressed in epidermis in 30% of normal skin compared to 20% of uninvolved epidermis and 63.3% of involved epidermis of psoriatic skin. MUC1 was seen staining endothelial cells of capillaries and inflammatory cells in dermis in 10% of normal skin, 0% of uninvolved psoriasis, and 83.3% of involved psoriasis. Dermal expression of MUC1 in psoriasis was associated with mild to moderate degrees of epidermal acanthosis ( ). Intense MUC1 expression by psoriatic epidermis was associated with short disease duration ( = .044). The upregulation of MUC1 in involved psoriatic lesion compared to uninvolved and normal skin may suggest MUC1 role in pathogenesis of psoriasis especially early stages. MUC1 may be responsible for less severity of psoriasis in old aged patients.
银屑病是一种具有免疫、过度增殖和血管生成功能障碍的慢性皮肤炎症性疾病。黏蛋白1（MUC1）是一种分子传感器和信号转导器，可对外界刺激作出反应，产生细胞反应，包括细胞增殖、生长、分化、迁移、侵袭、存活以及生长因子和细胞因子的分泌。本研究旨在通过MUC1在银屑病受累皮肤和未受累皮肤中的免疫组化定位，并与正常皮肤进行比较，此外还将MUC1表达与银屑病的临床和病理参数相关联，以评估MUC1在银屑病发病机制中的可能作用。本研究调查了30例银屑病患者和10例对照。在正常皮肤中，30%的表皮表达MUC1，而在银屑病未受累表皮中这一比例为20%，在受累表皮中为63.3%。在正常皮肤的10%、未受累银屑病皮肤的0%以及受累银屑病皮肤的83.3%中，可见MUC1对真皮中毛细血管内皮细胞和炎症细胞进行染色。银屑病中MUC1的真皮表达与轻度至中度的表皮棘层肥厚相关（ ）。银屑病表皮中MUC1的强烈表达与病程短相关（ = 0.044）。与未受累和正常皮肤相比，受累银屑病皮损中MUC1的上调可能提示MUC1在银屑病发病机制中尤其是早期阶段发挥作用。MUC1可能是老年患者银屑病病情较轻的原因。
