College of Enology, Northwest A&F University, Yangling, 712100, China.
Food Funct. 2020 Jul 1;11(7):6332-6339. doi: 10.1039/d0fo01177k.
Ellagic acid (EA), a natural polyphenol compound that exists in a variety of fruits and vegetables, has been reported to inhibit tumor growth by reducing cell growth, inducing apoptosis, and damaging mitochondria. Recent reports demonstrate that mitochondria regulate cancer cell death through energy metabolism and that different types of cell death coexist in vivo. We showed that EA inhibited lung cancer cell proliferation, markedly decreased ATP levels, decreased the potential of the inner mitochondrial membrane and decreased oxygen consumption in vitro. In addition, EA activated AMP-activated protein kinase (AMPK) and reduced HIF-1α in lung cancer cells. Moreover, the treatment of tumor-bearing mice with EA dramatically inhibited tumor growth, increased p-AMPK and suppressed HIF-1α levels. These findings suggest that EA could be a promising chemotherapeutic agent that targets mitochondrial metabolism in lung cancer.
鞣花酸（EA）是一种天然多酚化合物，存在于多种水果和蔬菜中，据报道可通过减少细胞生长、诱导细胞凋亡和破坏线粒体来抑制肿瘤生长。最近的报告表明，线粒体通过能量代谢调节癌细胞死亡，并且不同类型的细胞死亡在体内共存。我们发现 EA 抑制肺癌细胞增殖，显著降低 ATP 水平，降低线粒体膜电位并降低体外耗氧量。此外，EA 在肺癌细胞中激活 AMP 激活的蛋白激酶（AMPK）并降低 HIF-1α。此外，用 EA 治疗荷瘤小鼠可显著抑制肿瘤生长，增加 p-AMPK 并抑制 HIF-1α 水平。这些发现表明 EA 可能是一种有前途的化疗药物，可靶向肺癌中的线粒体代谢。
